Creating Diversity from Biomass: A Tandem Bio/Metal-Catalysis towards Chemoselective Synthesis of Densely Substituted Furans

Ravasco, João M. J. M.; Monteiro, Carlos M.; Siopa, Filipa; Trindade, Alexandre Fonseca; Oble, Julie; Poli, Giovanni; Simeonov, Svilen; Afonso, Carlos

http://hdl.handle.net/10451/59302

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Autores

Ravasco, João M. J. M.

Monteiro, Carlos M.

Siopa, Filipa

Trindade, Alexandre Fonseca

Resumo(s)

A new chemoselective (enzymatic desymmetrization/Ru-catalyzed C−H activation) sequence to obtain differently substituted furans from the largely available 2,5-furandicarboxylic acid (FDCA) was developed. Series of di- and trisubstituted furans were prepared in very good yields and excellent chemoselectivity. This study discloses a new approach towards valorization of the furanics platform through the use of FDCA as a stable intermediate, thus circumventing the chemical instability of the parent 5-hydroxymethylfurfural.

Descrição

Palavras-chave

biocatalysis biomass C-H activation continuous flow furanic platform

URI

http://hdl.handle.net/10451/59302

Citação

Ravasco JMJM, Monteiro CM, Siopa F, Trindade AF, Oble J, Poli G, et al. Creating diversity from biomass: a tandem bio/metal‐catalysis towards chemoselective synthesis of densely substituted furans. ChemSusChem [Internet]. 21 de outubro de 2019;12(20):4629–35. Disponível em: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cssc.201902051

Editora

Wiley-VCH Verlag

DOI

10.1002/cssc.201902051

Coleções

FF - CiênciaVitae - Faculdade de Farmácia

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