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Emergence of the same successful clade among distinct populations of emm89 Streptococcus pyogenes in multiple geographic regions

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dc.contributor.authorFriães, Ana
dc.contributor.authorMachado, Miguel P.
dc.contributor.authorPato, Catarina
dc.contributor.authorCarrico, Joao Andre
dc.contributor.authorCristino, José Melo
dc.contributor.authorRamirez, Mário
dc.date.accessioned2022-02-11T16:15:23Z
dc.date.available2022-02-11T16:15:23Z
dc.date.issued2015
dc.description© 2015 Friães et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.pt_PT
dc.description.abstractThe emergence of clades within emm89 Streptococcus pyogenes isolates that rapidly became the dominant lineages expressing this emm type was recently reported in the United Kingdom and in a study that included isolates from the United States, Finland, and Iceland (United States/FI/IC). In the United Kingdom, the emerging clade was associated with the absence of the hasABC locus, responsible for the synthesis of the hyaluronic acid capsule. The study from the United States/FI/IC highlighted the strict association of the emerging clade with an nga promoter variant, also found in contemporary emm1 isolates, which results in increased expression of the nga locus. The study from the United Kingdom also examined this region and found that the nga-ifs-slo locus and surrounding sequences of the emerging clade shared 99% DNA identity with that of contemporary emm1 and emm12 strains, but the authors do not offer any information on the nga promoter (1). The acquisition of this region by emm1 isolates is currently considered the major molecular event triggering the success and enhanced virulence of this clone.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationmBio 6(6):e01780-15pt_PT
dc.identifier.doi10.1128/mBio.01780-15pt_PT
dc.identifier.eissn2150-7511
dc.identifier.urihttp://hdl.handle.net/10451/51234
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Society for Microbiologypt_PT
dc.relation.publisherversionhttps://journals.asm.org/journal/mbiopt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.titleEmergence of the same successful clade among distinct populations of emm89 Streptococcus pyogenes in multiple geographic regionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.titlemBiopt_PT
oaire.citation.volume6pt_PT
person.familyNameAquino Friães
person.familyNameMachado
person.familyNameCarrico
person.familyNameMelo Cristino
person.familyNameRamos de Almeida Ramirez
person.givenNameAna Isabel
person.givenNameMiguel
person.givenNameJoao
person.givenNameJosé
person.givenNameMário Nuno
person.identifier391563
person.identifierB-4993-2008
person.identifier.ciencia-idB616-F64A-ACEF
person.identifier.ciencia-id3A18-725E-8CBE
person.identifier.ciencia-id871E-6AD6-F37C
person.identifier.ciencia-id9C1C-F2A2-4226
person.identifier.orcid0000-0002-7567-2405
person.identifier.orcid0000-0002-1786-8522
person.identifier.orcid0000-0002-5274-2722
person.identifier.orcid0000-0001-8643-1722
person.identifier.orcid0000-0002-4084-6233
person.identifier.ridF-6846-2015
person.identifier.ridA-7367-2008
person.identifier.ridH-3726-2013
person.identifier.scopus-author-id8266333200
person.identifier.scopus-author-id7004053640
person.identifier.scopus-author-id7201568476
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication18f75cbe-d083-419d-9441-a1a80e02465a
relation.isAuthorOfPublication3055d543-45c3-4f83-b394-c9aaac71bf4e
relation.isAuthorOfPublicatione4e2a0de-797a-4935-8b91-134efe7b784e
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relation.isAuthorOfPublication.latestForDiscovery18f75cbe-d083-419d-9441-a1a80e02465a

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