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Advisor(s)
Abstract(s)
Clinical, pathological, and immunohistochemical findings related to a feline mammary
tumor with similar features to canine anaplastic mammary carcinoma are herein described for the
first time. A female cat was presented for clinical evaluation with gastrointestinal signs, oedema,
erythema, and painful lesion in the right inguinal region. Three weeks later, the mass had doubled in
size and radiographic revaluation of the thoracic cavity revealed a metastatic pattern. Due to the
poor prognosis and decline of the clinical status the owners decided for euthanasia. Post-mortem
examination exposed a mammary tumoral mass with subcutaneous oedema, an enlargement of
the right inguinal lymph node, and nodules in several organs. Histological analysis confirmed the
presence of large pleomorphic epithelial cells, often grouped in small clusters with bizarre nuclei.
Immunohistochemical study of the different lesions was performed and both primary tumor and
regional metastasis showed tumor cells to be negative estrogen receptor alpha, positive progesterone
receptor, positive HER-2, and positive pan-cytokeratin. Given that the clinical history was compatible
with an inflammatory mammary carcinoma, the cyclooxygenase-2 expression levels were evaluated
and presented a weak immunoreactivity. Regarding the distant metastatic lesions, tumor cells were
negative for ER-α and PR and, positive both for HER-2 and pan-cytokeratin.
Description
Research Areas: Veterinary Sciences
Keywords
Anaplastic Feline mammary carcinoma Clinicopathological Immunohistochemical
Pedagogical Context
Citation
Soares M, Correia J, Nascimento C, Ferreira F. 2021. Anaplastic mammary carcinoma in cat. Veterinary Sciences, 8(5):77. Doi: 10.3390/vetsci8050077
Publisher
MDPI