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The influence of DNA methylation on monoallelic expression

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dc.contributor.authorda Rocha, Simão T.
dc.contributor.authorGendrel, Anne-Valerie
dc.date.accessioned2021-12-10T14:10:00Z
dc.date.available2021-12-10T14:10:00Z
dc.date.issued2019
dc.description© 2019 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).pt_PT
dc.description.abstractMonoallelic gene expression occurs in diploid cells when only one of the two alleles of a gene is active. There are three main classes of genes that display monoallelic expression in mammalian genomes: (1) imprinted genes that are monoallelically expressed in a parent-of-origin dependent manner; (2) X-linked genes that undergo random X-chromosome inactivation in female cells; (3) random monoallelically expressed single and clustered genes located on autosomes. The heritability of monoallelic expression patterns during cell divisions implies that epigenetic mechanisms are involved in the cellular memory of these expression states. Among these, methylation of CpG sites on DNA is one of the best described modification to explain somatic inheritance. Here, we discuss the relevance of DNA methylation for the establishment and maintenance of monoallelic expression patterns among these three groups of genes, and how this is intrinsically linked to development and cellular states.pt_PT
dc.description.sponsorshipThis work was supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES), Portugal, through the project grants PTDC/BEX-BCM/2612/2014 and PTDC/BIA-MOL/29320/2017 IC&DT. S.T.d.R. has a CEECUIND/01234/207 assistant research contract from FCT. A.-V.G. is supported by an INSERM investigator position. Publications costs were supported by UID/BIM/50005/2019, project funded by FCT/MCTES through Fundos do Orçamento de Estado.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEssays Biochem. 2019 Dec 20;63(6):663-676pt_PT
dc.identifier.doi10.1042/EBC20190034pt_PT
dc.identifier.eissn1744-1358
dc.identifier.issn0071-1365
dc.identifier.urihttp://hdl.handle.net/10451/50331
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPortland Presspt_PT
dc.relationCEECUIND/01234/207pt_PT
dc.relationInstituto de Medicina Molecular
dc.relation.publisherversionhttps://portlandpress.com/essaysbiochempt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectDNA methylationpt_PT
dc.subjectX-chromosome inactivationpt_PT
dc.subjectEpigeneticspt_PT
dc.subjectImprintingpt_PT
dc.subjectMonoallelic expressionpt_PT
dc.titleThe influence of DNA methylation on monoallelic expressionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleInstituto de Medicina Molecular
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBEX-BCM%2F2612%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MOL%2F29320%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIM%2F50005%2F2019/PT
oaire.citation.endPage676pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage663pt_PT
oaire.citation.titleEssays in Biochemistrypt_PT
oaire.citation.volume63pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameTeixeira da Rocha
person.familyNameGendrel
person.givenNameSimão José
person.givenNameAnne-Valerie
person.identifier.ciencia-id1310-8F0F-1387
person.identifier.ciencia-id1917-59ED-F318
person.identifier.orcid0000-0002-9683-7942
person.identifier.orcid0000-0003-4510-0024
person.identifier.ridE-5584-2017
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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