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Cognitive comorbidities of experimental absence seizures are independent of anxiety

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dc.contributor.authorNeuparth-Sottomayor, Mariana
dc.contributor.authorPina, Carolina
dc.contributor.authorMorais, Tatiana P.
dc.contributor.authorFarinha Ferreira, Jorge Miguel
dc.contributor.authorAbreu, Daniela Sofia
dc.contributor.authorSolano, Filipa
dc.contributor.authorMouro, Francisco
dc.contributor.authorGood, Mark
dc.contributor.authorSebastião, Ana M
dc.contributor.authorDi Giovanni, Giuseppe
dc.contributor.authorCrunelli, Vincenzo
dc.contributor.authorVaz, Sandra H.
dc.date.accessioned2025-06-12T15:24:27Z
dc.date.available2025-06-12T15:24:27Z
dc.date.issued2023
dc.description© 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractTypical absence seizures (ASs) are brief periods of lack of consciousness, associated with 2.5-4 Hz spike-wave discharges (SWDs) in the EEG, which are highly prevalent in children and teenagers. The majority of probands in these young epileptic cohorts show neuropsychological comorbidities, including cognitive, memory and mood impairments, even after the seizures are pharmacologically controlled. Similar cognition and memory deficits have been reported in different, but not all, genetic animal models of ASs. However, since these impairments are subtle and highly task-specific their presence may be confounded by an anxiety-like phenotype and no study has tested anxiety and memory in the same animals. Moreover, the majority of studies used non-epileptic inbred animals as the only control strain and this may have contributed to a misinterpretation of these behavioural results. To overcome these issues, here we used a battery of behavioural tests to compare anxiety and memory in the same animals from the well-established inbred model of Genetic Absence Epilepsy Rats from Strasbourg (GAERS), their inbred strain of Non-Epileptic Control (NEC) strain (that lack ASs) and normal outbred Wistar rats. We found that GAERS do not exhibit increased anxiety-like behavior and neophobia compared to both NEC and Wistar rats. In contrast, GAERS show decreased spontaneous alternation, spatial working memory and cross-modal object recognition compared to both NEC and Wistar rats. Furthermore, GAERS preferentially used egocentric strategies to perform spatial memory tasks. In summary, these results provide solid evidence of memory deficits in GAERS rats that do not depend on an anxiety or neophobic phenotype. Moreover, the presence of differences between NEC and Wistar rats stresses the need of using both outbred and inbred control rats in behavioural studies involving genetic models of ASs.pt_PT
dc.description.sponsorshipThis work was supported by the Fundação para a Ciência e para a Tecnologia (FCT) (grant PTDC/MED-FAR/30933/2017 to AMS and MNS and 2023.01003.BD to MNS), by the International Society for Neurochemistry (Carer Development Grant 2021 to SHV), the European Union (H2020-WIDESPREAD-05-2017-Twinning (EpiEpinet), grant agreement 952455, to AMS and SHV), the Malta Council for Science & Technology and the Foundation for Science and Technology (grant CanEpiRisk, to GDG), and the Ester Floridia Neuroscience Research Foundation (grant 1502 to VC). We would also like to acknowledge the Rodent Facility of Instituto de Fisiologia, Faculdade de Medicina (Universidade de Lisboa), for their technical support.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNeurobiol Dis. 2023 Oct 1:186:106275pt_PT
dc.identifier.doi10.1016/j.nbd.2023.106275pt_PT
dc.identifier.eissn1095-953X
dc.identifier.issn0969-9961
dc.identifier.urihttp://hdl.handle.net/10400.5/101548
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationIn the search of the synaptic mechanism operated by a novel selective antiepileptic drug
dc.relationHow do astrocytes control absence seizures and their comorbid cognitive deficits
dc.relationEpileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/neurobiology-of-diseasept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAbsence seizurespt_PT
dc.subjectAnxietypt_PT
dc.subjectAttention deficitspt_PT
dc.subjectGAERSpt_PT
dc.subjectMemory impairmentpt_PT
dc.subjectNECpt_PT
dc.subjectNeuropsychological comorbiditiespt_PT
dc.subjectWistarpt_PT
dc.titleCognitive comorbidities of experimental absence seizures are independent of anxietypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIn the search of the synaptic mechanism operated by a novel selective antiepileptic drug
oaire.awardTitleHow do astrocytes control absence seizures and their comorbid cognitive deficits
oaire.awardTitleEpileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-FAR%2F30933%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2023.01003.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/952455/EU
oaire.citation.titleNeurobiology of Diseasept_PT
oaire.citation.volume186pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamH2020
person.familyNameSerra de Sequeira Neuparth Sottomayor
person.familyNameFarinha Ferreira
person.familyNameda Costa Abreu
person.familyNameMouro
person.familyNameSebastião
person.familyNameHenriques Vaz
person.givenNameMariana
person.givenNameJorge Miguel
person.givenNameDaniela Sofia
person.givenNameFrancisco
person.givenNameAna M
person.givenNameSandra Cristina
person.identifier548147
person.identifier.ciencia-id6B1E-0623-D291
person.identifier.ciencia-idE416-A9B5-8059
person.identifier.ciencia-idE018-22E1-F4B3
person.identifier.ciencia-idF112-55E8-E37E
person.identifier.ciencia-id0E1C-952D-61BE
person.identifier.orcid0000-0002-2309-0171
person.identifier.orcid0000-0003-1240-0717
person.identifier.orcid0000-0002-6579-3596
person.identifier.orcid0000-0002-7141-8418
person.identifier.orcid0000-0001-9030-6115
person.identifier.orcid0000-0003-4258-9397
person.identifier.scopus-author-id7004409879
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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