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Innate recognition of malarial parasites by mammalian hosts

2012-05-15Artigo científico Acesso restrito
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dc.contributor.authorLiehl, Peter
dc.contributor.authorMota, Maria M.
dc.date.accessioned2021-07-20T13:36:18Z
dc.date.available2021-07-20T13:36:18Z
dc.date.issued2012-05-15
dc.descriptionCopyright © 2012 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.pt_PT
dc.description.abstractInnate immunity plays a central role in combating infections. However, the importance of innate immune sensors in detecting intracellular parasites, such as Plasmodium spp., has only recently emerged as a central topic in the field of host-pathogen interactions. Genetic dissection of innate immune pathways has uncovered a complex relationship between the host innate immune system and Plasmodium blood-stage parasites. In fact, recognition molecules of the innate immune system, such as toll-like receptors, might not only be implicated in host defense but also in the pathogenesis of the disease. Whether Plasmodium liver stage parasites are recognised and controlled by the host innate immune system remains to be discovered. In this review we discuss recent findings on how the host innate immune system may sense and fight the different forms of Plasmodium and how the latter may have evolved mechanisms to escape host detection and/or to manipulate the defensive reaction of the host.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Parasitol. 2012 May 15;42(6):557-566pt_PT
dc.identifier.doi10.1016/j.ijpara.2012.04.006pt_PT
dc.identifier.eissn1879-0135
dc.identifier.issn0020-7519
dc.identifier.urihttp://hdl.handle.net/10451/49031
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/international-journal-for-parasitologypt_PT
dc.subjectPlasmodiumpt_PT
dc.subjectSporozoitespt_PT
dc.subjectCerebral malariapt_PT
dc.subjectPattern recognition receptorspt_PT
dc.subjectParasite ligandspt_PT
dc.subjectImmune evasionpt_PT
dc.titleInnate recognition of malarial parasites by mammalian hostspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage566pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage557pt_PT
oaire.citation.titleInternational Journal for Parasitologypt_PT
oaire.citation.volume42pt_PT
person.familyNameLiehl
person.familyNameMota
person.givenNamePeter
person.givenNameMaria Manuel
person.identifier.ciencia-id4217-0969-297E
person.identifier.orcid0000-0002-8040-2303
person.identifier.orcid0000-0002-2858-1041
person.identifier.scopus-author-id7102709816
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication941a60d6-0d30-448f-80fe-845af30e991a
relation.isAuthorOfPublication0c93cb69-f8fb-4247-8e71-bb9b84de368c
relation.isAuthorOfPublication.latestForDiscovery941a60d6-0d30-448f-80fe-845af30e991a

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