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Publicação
Innate recognition of malarial parasites by mammalian hosts
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Autores
Orientador(es)
Resumo(s)
Innate immunity plays a central role in combating infections. However, the importance of innate immune sensors in detecting intracellular parasites, such as Plasmodium spp., has only recently emerged as a central topic in the field of host-pathogen interactions. Genetic dissection of innate immune pathways has uncovered a complex relationship between the host innate immune system and Plasmodium blood-stage parasites. In fact, recognition molecules of the innate immune system, such as toll-like receptors, might not only be implicated in host defense but also in the pathogenesis of the disease. Whether Plasmodium liver stage parasites are recognised and controlled by the host innate immune system remains to be discovered. In this review we discuss recent findings on how the host innate immune system may sense and fight the different forms of Plasmodium and how the latter may have evolved mechanisms to escape host detection and/or to manipulate the defensive reaction of the host.
Descrição
Copyright © 2012 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
Palavras-chave
Plasmodium Sporozoites Cerebral malaria Pattern recognition receptors Parasite ligands Immune evasion
Contexto Educativo
Citação
Int J Parasitol. 2012 May 15;42(6):557-566
Editora
Elsevier