Tubulointerstitial nephritis and uveitis TINU syndrome : a review

Amaro, David; Carreño, Ester; Steeples, Laura R.; Oliveira Ramos, Filipa; Marques-Neves, Carlos; Leal, Ines

http://hdl.handle.net/10451/46790

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
Tubulointerstitial_nephritis.pdf		289.42 KB	Adobe PDF	Download

Send Feedback

Authors

Amaro, David

Carreño, Ester

Steeples, Laura R.

Oliveira Ramos, Filipa

Marques-Neves, Carlos

Leal, Ines

Abstract(s)

Inflammation of renal interstitium and uveal tissue establishes the two components of tubulointerstitial nephritis and uveitis (TINU) syndrome. Although believed to occur more frequently in young females, a broad spectrum of patients can be affected. Both renal and eye disease can be asymptomatic and may not manifest simultaneously, having independent progressions. Renal disease manifests as acute kidney injury and may cause permanent renal impairment. Eye inflammation can manifest in different anatomical forms, most commonly as bilateral anterior uveitis and may progress to a chronic course. TINU syndrome accounts for approximately 1%–2% of uveitis in tertiary referral centres. A literature review covering the clinical features, pathogenesis, diagnosis and treatment is presented.