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Orthostatic stress and baroreflex sensitivity: a window into autonomic dysfunction in lone paroxysmal atrial fibrillation

2023Journal article Open access
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dc.contributor.authorFerreira, Mónica
dc.contributor.authorLaranjo, Sergio
dc.contributor.authorCunha, Pedro
dc.contributor.authorGeraldes, Vera
dc.contributor.authorOliveira, Mario
dc.contributor.authorRocha, Isabel
dc.date.accessioned2023-10-18T14:27:45Z
dc.date.available2023-10-18T14:27:45Z
dc.date.issued2023
dc.description© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractThe abnormal neural control of atria has been considered one of the mechanisms of paroxysmal atrial fibrillation (PAF) pathogenesis. The baroreceptor reflex has an important role in cardiovascular regulation and may serve as an index of autonomic function. This study aimed to analyze the baroreceptor reflex's role in heart rate regulation during upright tilt (HUT) in patients with lone PAF. The study included 68 patients with lone PAF and 34 healthy individuals who underwent baroreflex assessment. Parameters such as baroreflex sensitivity (BRS), number of systolic blood pressure (BP) ramps, and the baroreflex effectiveness index (BEI) were evaluated. The study found that PAF patients had comparable resting BPs and heart rates (HRs) to healthy individuals. However, unlike healthy individuals, PAF patients showed a sustained increase in BP with an upright posture followed by the delayed activation of the baroreceptor function with a blunted HR response and lower BEI values. This indicates a pronounced baroreflex impairment in PAF patients, even at rest. Our data suggest that together with BRS, BEI could be used as a marker of autonomic dysfunction in PAF patients, making it important to further investigate its relationship with AF recurrence after ablation and its involvement in cardiovascular autonomic remodeling.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Clin Med. 2023 Sep 8;12(18):5857pt_PT
dc.identifier.doi10.3390/jcm12185857pt_PT
dc.identifier.eissn2077-0383
dc.identifier.urihttp://hdl.handle.net/10451/59887
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/journal/jcmpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAtrial fibrillationpt_PT
dc.subjectAutonomic functionpt_PT
dc.subjectBaroreceptor reflexpt_PT
dc.subjectBaroreflex effectiveness indexpt_PT
dc.subjectBaroreflex gainpt_PT
dc.titleOrthostatic stress and baroreflex sensitivity: a window into autonomic dysfunction in lone paroxysmal atrial fibrillationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue18pt_PT
oaire.citation.titleJournal of Clinical Medicinept_PT
oaire.citation.volume12pt_PT
person.familyNameFerreira
person.familyNameLaranjo
person.familyNameSilva Cunha
person.familyNameGeraldes
person.familyNameMartins Oliveira
person.familyNamerocha
person.givenNameMónica
person.givenNameSergio
person.givenNamePedro Miguel
person.givenNameVera
person.givenNameMario Joao
person.givenNameisabel
person.identifier36332
person.identifier.ciencia-id6C1E-26F2-E6A4
person.identifier.ciencia-id351B-92E1-0C50
person.identifier.ciencia-id4716-747F-D64E
person.identifier.ciencia-idD51D-E96C-1633
person.identifier.ciencia-id2312-2190-19B2
person.identifier.orcid0000-0002-7066-7770
person.identifier.orcid0000-0003-2169-4024
person.identifier.orcid0000-0001-9465-634X
person.identifier.orcid0000-0003-1275-3459
person.identifier.orcid0000-0002-8371-8354
person.identifier.orcid0000-0002-7582-0893
person.identifier.ridG-2909-2011
person.identifier.ridM-4137-2013
person.identifier.scopus-author-id24391148400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication074e158a-578a-4d50-bbc7-56869253e9a5
relation.isAuthorOfPublication902d64d7-c6bf-4b05-8f49-3b52dd0aa452
relation.isAuthorOfPublication77292f94-3ad4-4657-bba0-c54ab9dd641a
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relation.isAuthorOfPublication81e0b444-8832-47a8-a911-2f89eb33545d
relation.isAuthorOfPublication472714e8-fa6c-4d7b-9c4d-d6f5b55e39f4
relation.isAuthorOfPublication.latestForDiscovery902d64d7-c6bf-4b05-8f49-3b52dd0aa452

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