Repository logo
 
Publication

Anti-HIV-1 activity of pepRF1, a proteolysis-resistant CXCR4 antagonist derived from Dengue virus capsid protein

2020Journal article Restricted access
Simple item page
dc.contributor.authorCadima Couto, Carla Iris
dc.contributor.authorTauzin, Alexandra
dc.contributor.authorFreire, João Miguel
dc.contributor.authorFigueira, Tiago N.
dc.contributor.authorSilva, Rúben D. M.
dc.contributor.authorPérez-Peinado, Clara
dc.contributor.authorCunha-Santos, Catarina
dc.contributor.authorBártolo, Inês
dc.contributor.authorTaveira, Nuno
dc.contributor.authorGano, Lurdes
dc.contributor.authorCorreia, João D. G.
dc.contributor.authorGoncalves, Joao
dc.contributor.authorMammano, Fabrizio
dc.contributor.authorAndreu, David
dc.contributor.authorCastanho, Miguel A. R. B.
dc.contributor.authorVeiga, Ana Salomé
dc.date.accessioned2021-04-06T11:19:42Z
dc.date.available2021-04-06T11:19:42Z
dc.date.issued2020
dc.descriptionCopyright © 2020 American Chemical Societypt_PT
dc.description.abstractThere is an urgent need for the development of new anti-HIV drugs that can complement existing medicines to be used against resistant strains. Here, we report the anti-HIV-1 peptide pepRF1, a human serum-resistant peptide derived from the Dengue virus capsid protein. In vitro, pepRF1 shows a 50% inhibitory concentration of 1.5 nM with a potential therapeutic window higher than 53 000. This peptide is specific for CXCR4-tropic strains, preventing viral entry into target cells by binding to the viral coreceptor CXCR4, acting as an antagonist of this receptor. pepRF1 is more effective than T20, the only peptide-based HIV-1 entry inhibitor approved, and excels in inhibiting a HIV-1 strain resistant to T20. Potentially, pepRF1 can be used alone or in combination with other anti-HIV drugs. Furthermore, one can also envisage its use as a novel therapeutic strategy for other CXCR4-related diseases.pt_PT
dc.description.sponsorshipThis work was supported by Fundação para a Ciência e aTecnologia (FCT-MCTES, Portugal) project PTDC/QEQ-MED/4412/2014, and by the Institut National de la Santéetde la Recherche Médicale (Inserm). I.C.C., J.M.F., T.N.F., and I.B. acknowledge fellowships SFRH/BPD/65531/2009,SFRH/BD/70423/2010, SFRH/BD/5283/2013, and SFRH/BPD/76225/2011, respectively, funded by FCT-MCTES. A.T. is the recipient of a fellowship from Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS). A.S.V.acknowledges funding under the Investigator Programme (IF/00803/2012) from FCT-MCTES. Work at Pompeu Fabra University was supported by grants AGL2014-52395-C2 and AGL2017-84097-C2-2-R and by the“María de Maeztu”Program for Units of Excellence in R&D from the Spanish Ministry of Innovation and Competitiveness (MINECO).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationACS Infect Dis. 2021 Jan 8;7(1):6-22pt_PT
dc.identifier.doi10.1021/acsinfecdis.9b00507pt_PT
dc.identifier.eissn2373-8227
dc.identifier.urihttp://hdl.handle.net/10451/47245
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherACS Publicationspt_PT
dc.relationSFRH/BD/5283/2013pt_PT
dc.relationTowards the development of innovative highly effective dual action anti-HIV peptides
dc.relationMULTI-TARGET HIV ENTRY INHIBITORS DELIVERY BY CATIONIC LIPOSOMES
dc.relationDESENVOLVIMENTO DE NOVOS MICROBICIDAS PARA PREVENIR A INFECÇÃO POR VIH
dc.relation.publisherversionhttps://pubs.acs.org/journal/aidcbcpt_PT
dc.subjectCXCR4pt_PT
dc.subjectHIVpt_PT
dc.subjectAntagonistpt_PT
dc.subjectAntiviral drugspt_PT
dc.subjectPeptidept_PT
dc.titleAnti-HIV-1 activity of pepRF1, a proteolysis-resistant CXCR4 antagonist derived from Dengue virus capsid proteinpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTowards the development of innovative highly effective dual action anti-HIV peptides
oaire.awardTitleMULTI-TARGET HIV ENTRY INHIBITORS DELIVERY BY CATIONIC LIPOSOMES
oaire.awardTitleDESENVOLVIMENTO DE NOVOS MICROBICIDAS PARA PREVENIR A INFECÇÃO POR VIH
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQEQ-MED%2F4412%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F65531%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F70423%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F76225%2F2011/PT
oaire.citation.endPage22pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage6pt_PT
oaire.citation.titleACS Infectious Diseasespt_PT
oaire.citation.volume7pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFARH
oaire.fundingStreamSFRH
person.familyNamecadima couto
person.familyNameMiguel Freire
person.familyNameFigueira
person.familyNameCunha-Santos
person.familyNameBártolo
person.familyNameTaveira
person.familyNameBarrela Patricio Gano
person.familyNameCorreia
person.familyNameGoncalves
person.familyNameCastanho
person.familyNameVeiga
person.givenNamecarla iris
person.givenNameJoão
person.givenNameTiago
person.givenNameCatarina
person.givenNameInês
person.givenNameNuno
person.givenNameMaria Lurdes
person.givenNameJoão
person.givenNameJoao
person.givenNameMiguel
person.givenNameAna Salome
person.identifierJ-6929-2013
person.identifier1064683
person.identifier.ciencia-idE615-4D15-C5EB
person.identifier.ciencia-id661E-F5CB-F85A
person.identifier.ciencia-id7111-3383-A926
person.identifier.ciencia-idC11F-51E3-6084
person.identifier.ciencia-idEC11-F3E9-78A2
person.identifier.ciencia-idB11B-9815-C46F
person.identifier.orcid0000-0001-7398-5857
person.identifier.orcid0000-0002-8674-0813
person.identifier.orcid0000-0002-0813-0745
person.identifier.orcid0000-0001-8789-1966
person.identifier.orcid0000-0002-2022-8921
person.identifier.orcid0000-0003-0176-5585
person.identifier.orcid0000-0001-7186-2060
person.identifier.orcid0000-0002-7847-4906
person.identifier.orcid0000-0002-1245-3715
person.identifier.orcid0000-0001-7891-7562
person.identifier.orcid0000-0002-9892-2243
person.identifier.ridJ-4881-2015
person.identifier.ridJ-7036-2013
person.identifier.ridB-2013-2008
person.identifier.scopus-author-id8976995900
person.identifier.scopus-author-id7202364104
person.identifier.scopus-author-id7103326175
person.identifier.scopus-author-id56605575600
person.identifier.scopus-author-id56745037100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication231c5019-ce0e-4da1-bda2-1f17c11e7bfa
relation.isAuthorOfPublicationc7150f6b-58fc-4485-bf21-47cb8fc344e7
relation.isAuthorOfPublicationc65d67d4-bb09-45c4-be75-376e1f048665
relation.isAuthorOfPublication0a33a87e-414a-44da-9685-641ff2103043
relation.isAuthorOfPublicationb5f3db05-baf4-4d91-99c7-581e4c7b2e74
relation.isAuthorOfPublicationd62b22f8-7ce6-4bb2-ac55-2117707f6612
relation.isAuthorOfPublication032ea886-49b5-40c6-bb5f-5cb7db74efaf
relation.isAuthorOfPublicationffc14ae3-9775-41bf-a353-d7ded14bf152
relation.isAuthorOfPublication59510be6-ca25-4f49-a4bb-8236d799fbe4
relation.isAuthorOfPublicationf5e46f85-fabf-450a-9ee2-1c7b59410892
relation.isAuthorOfPublicatione4303354-5eaa-4d48-8198-de1adc9beb19
relation.isAuthorOfPublication.latestForDiscovery59510be6-ca25-4f49-a4bb-8236d799fbe4
relation.isProjectOfPublicationa2c45420-c77a-4e90-bb81-9a99fff4e756
relation.isProjectOfPublication82e741a8-1495-4f3f-be61-58028c19a625
relation.isProjectOfPublication1a004e63-0ace-4b41-bd0c-db90b919807e
relation.isProjectOfPublicatione3b7c207-d129-4c0c-b2b0-ea8199cad9f8
relation.isProjectOfPublication.latestForDiscovery82e741a8-1495-4f3f-be61-58028c19a625

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Anti_HIV1.pdf
Size:
2.85 MB
Format:
Adobe Portable Document Format
Download

Collections

IMM - Artigos em Revistas Internacionais
FM - Artigos em Revistas Internacionais