Repository logo
 
Publication

Thiamine compounds alleviate oxidative stress, over-expression of pro-inflammatory markers and behavioral abnormalities in a mouse predation model of PTSD

2025Journal article Open access
Simple item page
dc.contributor.authorStrekalova, Tatyana
dc.contributor.authorGorlova, Anna
dc.contributor.authorNunes, João
dc.contributor.authorLitavrin, Aleksandr
dc.contributor.authorMunter, Johannes P. M. de
dc.contributor.authorLyundup, Alexei
dc.contributor.authorUmriukhin, Aleksei
dc.contributor.authorProshin, Andrey
dc.contributor.authorKalueff, Allan
dc.contributor.authorGrünblatt, Edna
dc.contributor.authorWalitza, Susanna
dc.date.accessioned2025-08-01T10:48:29Z
dc.date.available2025-08-01T10:48:29Z
dc.date.issued2025
dc.description© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractExperiences of life-threatening stimuli can induce post-traumatic stress disorder (PTSD), which is associated with long-lasting behavioral and neurochemical abnormalities. Despite its increased global incidence, the current treatment options for PTSD remain limited, highlighting the need for novel therapeutic strategies. As oxidative stress and neuroinflammation contribute to PTSD, the use of powerful antioxidants such as thiamine (B1 vitamin) compounds may counteract disease development. Young C57BL/6 mice received thiamine or benfotiamine in drinking water (each at a dose of 200 mg/kg/day) for 21 days, and for the last five days, they were subjected to rat exposure. Mice were studied for anxiety-like behavior, exploration, locomotion, grooming, social interactions, pain sensitivity, brain changes in protein carbonyl (PC), total glutathione (TG), and gene expression of distress and inflammation markers. Rat exposure induced anxiety-like behavior, excessive grooming, and alteration in locomotion, along with other abnormalities. Stressed, untreated mice had elevated levels of PC and TG in the prefrontal cortex, hippocampus, amygdala, and striatum and increased expression of Il-1β, Tnf, c-Fos, Cox-1, and Cox-2. Treatment with thiamine or benfotiamine significantly ameliorated most of these changes in the stressed groups. Thus, thiamine compounds may have therapeutic potential in patients with PTSD, owing to their antioxidant and anti-inflammatory properties.pt_PT
dc.description.sponsorshipThis study was supported by Research Russia-Switzerland Grant-2020 (all experimental work was carried out by January 2022) to SW and TS and PhytoAPP EU framework (2021–2025, to TS). The PhytoAPP project has received funding from the European Union’s HORIZON 2020 research and innovation program under the Marie Skłodowvska-Curie grant agreement 101007642.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Mol Sci. 2025 Jul 10;26(14):6627pt_PT
dc.identifier.doi10.3390/ijms26146627pt_PT
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10400.5/102614
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationINNOVATIVE WATER-SOLUBLE PHYTOMATERIAL INHIBITORs FOR ALZHEIMERs AND PARKINSONs DISEASES PREVENTION
dc.relation.publisherversionhttps://www.mdpi.com/journal/ijmspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimal modelpt_PT
dc.subjectAnxiety-like behaviorpt_PT
dc.subjectBenfotiaminept_PT
dc.subjectMicept_PT
dc.subjectNeuroinflammationpt_PT
dc.subjectOxidative stresspt_PT
dc.subjectPosttraumatic stress disorder (PTSD)pt_PT
dc.subjectPredator stresspt_PT
dc.subjectThiamine (vitamin B1)pt_PT
dc.titleThiamine compounds alleviate oxidative stress, over-expression of pro-inflammatory markers and behavioral abnormalities in a mouse predation model of PTSDpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleINNOVATIVE WATER-SOLUBLE PHYTOMATERIAL INHIBITORs FOR ALZHEIMERs AND PARKINSONs DISEASES PREVENTION
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/101007642/EU
oaire.citation.issue14pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume26pt_PT
oaire.fundingStreamH2020
person.familyNameda Costa Alvares Viegas Nunes
person.givenNameJoão Pedro
person.identifierQ-8648-2017
person.identifier.ciencia-idF413-C6F8-AFF1
person.identifier.orcid0000-0003-0127-5420
person.identifier.scopus-author-id55974674700
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication571fa049-46ca-4e54-b555-23993a7e78ca
relation.isAuthorOfPublication.latestForDiscovery571fa049-46ca-4e54-b555-23993a7e78ca
relation.isProjectOfPublicationbef87d58-605b-49c9-b75d-d8eac1ad1cea
relation.isProjectOfPublication.latestForDiscoverybef87d58-605b-49c9-b75d-d8eac1ad1cea

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Thiamine_compounds.pdf
Size:
2.16 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FM - Artigos em Revistas Internacionais