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One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia

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dc.contributor.authorBarkham, Timothy
dc.contributor.authorZadoks, Ruth N.
dc.contributor.authorAzmai, Mohammad Noor Amal
dc.contributor.authorBaker, Stephen
dc.contributor.authorBich, Vu Thi Ngoc
dc.contributor.authorChalker, Victoria
dc.contributor.authorChau, Man Ling
dc.contributor.authorDance, David
dc.contributor.authorDeepak, Rama Narayana
dc.contributor.authorvan Doorn, H. Rogier
dc.contributor.authorGutierrez, Ramona A.
dc.contributor.authorHolmes, Mark A.
dc.contributor.authorHuong, Lan Nguyen Phu
dc.contributor.authorKoh, Tse Hsien
dc.contributor.authorMartins, Elisabete R.
dc.contributor.authorMehershahi, Kurosh
dc.contributor.authorNewton, Paul
dc.contributor.authorNg, Lee Ching
dc.contributor.authorPhuoc, Nguyen Ngoc
dc.contributor.authorSangwichian, Ornuma
dc.contributor.authorSawatwong, Pongpun
dc.contributor.authorSurin, Uraiwan
dc.contributor.authorTan, Thean Yen
dc.contributor.authorTang, Wen Ying
dc.contributor.authorThuy, Nguyen Vu
dc.contributor.authorTurner, Paul
dc.contributor.authorVongsouvath, Manivanh
dc.contributor.authorZhang, Defeng
dc.contributor.authorWhistler, Toni
dc.contributor.authorChen, Swaine L.
dc.date.accessioned2022-05-13T15:29:46Z
dc.date.available2022-05-13T15:29:46Z
dc.date.issued2019
dc.descriptionThis is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.pt_PT
dc.description.abstractBackground: In 2015, Singapore had the first and only reported foodborne outbreak of invasive disease caused by the group B Streptococcus (GBS; Streptococcus agalactiae). Disease, predominantly septic arthritis and meningitis, was associated with sequence type (ST)283, acquired from eating raw farmed freshwater fish. Although GBS sepsis is well-described in neonates and older adults with co-morbidities, this outbreak affected non-pregnant and younger adults with fewer co-morbidities, suggesting greater virulence. Before 2015 ST283 had only been reported from twenty humans in Hong Kong and two in France, and from one fish in Thailand. We hypothesised that ST283 was causing region-wide infection in Southeast Asia. Methodology/principal findings: We performed a literature review, whole genome sequencing on 145 GBS isolates collected from six Southeast Asian countries, and phylogenetic analysis on 7,468 GBS sequences including 227 variants of ST283 from humans and animals. Although almost absent outside Asia, ST283 was found in all invasive Asian collections analysed, from 1995 to 2017. It accounted for 29/38 (76%) human isolates in Lao PDR, 102/139 (73%) in Thailand, 4/13 (31%) in Vietnam, and 167/739 (23%) in Singapore. ST283 and its variants were found in 62/62 (100%) tilapia from 14 outbreak sites in Malaysia and Vietnam, in seven fish species in Singapore markets, and a diseased frog in China. Conclusions: GBS ST283 is widespread in Southeast Asia, where it accounts for a large proportion of bacteraemic GBS, and causes disease and economic loss in aquaculture. If human ST283 is fishborne, as in the Singapore outbreak, then GBS sepsis in Thailand and Lao PDR is predominantly a foodborne disease. However, whether transmission is from aquaculture to humans, or vice versa, or involves an unidentified reservoir remains unknown. Creation of cross-border collaborations in human and animal health are needed to complete the epidemiological picture.pt_PT
dc.description.sponsorshipSupport for this project was provided by the Molecular Biology Laboratory and the Department of Laboratory Medicine, Tan Tock Seng Hospital; by the Environmental Health Institute, National Environment Agency, Singapore; by the Ministry of Health, Singapore, through the Singapore Infectious Diseases Initiative grant number SIDI/2016/002 (TB) https://www.moh.gov.sg, and the National Medical Research Council, Ministry of Health, Singapore grant number NMRC/CIRG/1467/2017 (SLC) http://www.nmrc.gov.sg, by the UK Global Challenges Research Fund via the Scottish Funding Council, SFC/AN/10/2018 (RNZ) http://www.sfc.ac.uk, and by the Global Disease Detection program of the U.S. Centers for Disease Control and Prevention.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPLoS Negl Trop Dis. 2019 Jun 27;13(6):e0007421pt_PT
dc.identifier.doi10.1371/journal.pntd.0007421pt_PT
dc.identifier.eissn1935-2735
dc.identifier.issn1935-2727
dc.identifier.urihttp://hdl.handle.net/10451/52995
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPLoSpt_PT
dc.relation.publisherversionhttps://journals.plos.org/plosntds/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleOne hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asiapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.titlePLOS Neglected Tropical Diseasespt_PT
oaire.citation.volume13pt_PT
person.familyNameMartins
person.givenNameElisabete
person.identifier.ciencia-id0C1E-2896-F1AE
person.identifier.orcid0000-0002-0703-9982
person.identifier.ridA-2607-2009
person.identifier.scopus-author-id22835470900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd605b4bc-fc4b-4175-ad18-3fed061fa2f9
relation.isAuthorOfPublication.latestForDiscoveryd605b4bc-fc4b-4175-ad18-3fed061fa2f9

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