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Origin and epidemiological history of HIV-1 CRF14_BG

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dc.contributor.authorBártolo, Inês
dc.contributor.authorAbecasis, Ana B.
dc.contributor.authorBorrego, Pedro
dc.contributor.authorBarroso, Helena
dc.contributor.authorMcCutchan, Francine
dc.contributor.authorGomes, Perpetua
dc.contributor.authorCamacho, Ricardo
dc.contributor.authorTaveira, Nuno
dc.date.accessioned2023-08-31T12:20:25Z
dc.date.available2023-08-31T12:20:25Z
dc.date.issued2011
dc.date.updated2023-02-03T14:38:39Z
dc.description.abstractBackground CRF14_BG isolates, originally found in Spain, are characterized by CXCR4 tropism and rapid disease progression. This study aimed to identify the origin of CRF14_BG and reconstruct its epidemiological history based on new isolates from Portugal. Methodology/Principal Findings C2V3C3 env gene sequences were obtained from 62 samples collected in 1993–1998 from Portuguese HIV-1 patients. Full-length genomic sequences were obtained from three patients. Viral subtypes, diversity, divergence rate and positive selection were investigated by phylogenetic analysis. The molecular structure of the genomes was determined by bootscanning. A relaxed molecular clock model was used to date the origin of CRF14_BG. Geno2pheno was used to predict viral tropism. Subtype B was the most prevalent subtype (45 sequences; 73%) followed by CRF14_BG (8; 13%), G (4; 6%), F1 (2; 3%), C (2; 3%) and CRF02_AG (1; 2%). Three CRF14_BG sequences were derived from 1993 samples. Near full-length genomic sequences were strongly related to the CRF14_BG isolates from Spain. Genetic diversity of the Portuguese isolates was significantly higher than the Spanish isolates (0.044 vs 0.014, P<0.0001). The mean date of origin of the CRF14_BG cluster was estimated to be 1992 (range, 1989 and 1996) based on the subtype G genomic region and 1989 (range, 1984–1993) based on the subtype B genomic region. Most CRF14_BG strains (78.9%) were predicted to be CXCR4. Finally, up to five amino acids were under selective pressure in subtype B V3 loop whereas only one was found in the CRF14_BG cluster. Conclusions CRF14_BG emerged in Portugal in the early 1990 s soon after the beginning of the HIV-1 epidemics, spread to Spain in late 1990 s as a consequence of IVDUs migration and then to the rest of Europe. CXCR4 tropism is a general characteristic of this CRF that may have been selected for by escape from neutralizing antibody response.pt_PT
dc.description.sponsorshipThis work was supported by grant PTDC/SAU-FCF/67673/2006 from Fundação para a Ciência e Tecnologia Portugal, and by CHAIN (Collaborative HIV and Anti-HIV Drug Resistance Network), European Union. Inês Bártolo and Pedro Borrego are recipients of PhD scholarships from Fundação para a Ciência e Tecnologia (FCT), Portugal. Ana Abecasis is supported by a Post-Doc grant from the Fundação para a Ciência e Tecnologia (FCT), Portugal (SFRH/BPD/65605/2009). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBártolo I, Abecasis AB, Borrego P, Barroso H, McCutchan F, Gomes P, et al. Origin and epidemiological history of hiv-1 crf14_bg. PLOS ONE [Internet]. 28 de setembro de 2011;6(9):e24130. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024130pt_PT
dc.identifier.doi10.1371/journal.pone.0024130pt_PT
dc.identifier.eid2-s2.0-80053252119
dc.identifier.slugcv-prod-1108461
dc.identifier.urihttp://hdl.handle.net/10451/59101
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPlospt_PT
dc.relationCollaborative HIV and Anti-HIV Drug Resistance Network
dc.relationCOMPARATIVE STUDY OF THE SELECTIVE PRESSURE, REPLICATION AND TRANSMISSION DYNAMICS OF HIV-1 SUBTYPES
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024130pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleOrigin and epidemiological history of HIV-1 CRF14_BGpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPTDC/SAU-FCF/67673/2006
oaire.awardNumber223131
oaire.awardNumberSFRH/BPD/65605/2009
oaire.awardTitleCollaborative HIV and Anti-HIV Drug Resistance Network
oaire.awardTitleCOMPARATIVE STUDY OF THE SELECTIVE PRESSURE, REPLICATION AND TRANSMISSION DYNAMICS OF HIV-1 SUBTYPES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-FCF%2F67673%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/223131/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F65605%2F2009/PT
oaire.citation.issue9pt_PT
oaire.citation.startPagee24130pt_PT
oaire.citation.titlePLoS ONEpt_PT
oaire.citation.volume6pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFP7
person.familyNameBártolo
person.familyNameAbecasis
person.familyNameBorrego
person.familyNameBarroso
person.familyNameRodrigues Gomes Cavaco Silva
person.familyNameTaveira
person.givenNameInês
person.givenNameAna
person.givenNamePedro
person.givenNameHelena
person.givenNamePerpétua da Conceição
person.givenNameNuno
person.identifier652473
person.identifier.ciencia-id661E-F5CB-F85A
person.identifier.ciencia-id0817-056B-9B7C
person.identifier.ciencia-idA71C-0177-722F
person.identifier.ciencia-idE311-7ACE-373D
person.identifier.ciencia-id7219-B8D3-2942
person.identifier.ciencia-id7111-3383-A926
person.identifier.orcid0000-0002-2022-8921
person.identifier.orcid0000-0002-3903-5265
person.identifier.orcid0000-0002-1949-9484
person.identifier.orcid0000-0003-4098-5433
person.identifier.orcid0000-0003-3271-8255
person.identifier.orcid0000-0003-0176-5585
person.identifier.ridB-6295-2009
person.identifier.ridH-6968-2013
person.identifier.scopus-author-id8835604200
person.identifier.scopus-author-id25225039400
person.identifier.scopus-author-id35492841400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid661E-F5CB-F85A | Inês Bártolo
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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