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Glial plasticity in depression

2016Journal article Open access
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dc.contributor.authorOliveira, João F.
dc.contributor.authorGomes, Catarina A.
dc.contributor.authorVaz, Sandra H.
dc.contributor.authorSousa, Nuno
dc.contributor.authorPinto, Luisa
dc.date.accessioned2021-07-29T13:45:58Z
dc.date.available2021-07-29T13:45:58Z
dc.date.issued2016
dc.descriptionCopyright © 2016 Oliveira, Gomes, Vaz, Sousa and Pinto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractDepression is a highly prevalent disorder that poses a significant social burden to society. Despite continued advances toward the understanding of the pathophysiology of this disease, its molecular/cellular underpinnings remain elusive, which may be at the basis of the lack of effective treatment strategies. Among the different lines of research, recent literature suggests that impaired neuron and glial plasticity may be a key underlying mechanism in the precipitation of the disorder. Surprisingly, glial cells appear to be involved both in the pathophysiology of major depression and in the action of antidepressants. In particular, several works refer to alterations in the morphology and numbers of astrocytes, microglia, and oligodendrocytes in the context of depression, in human patients, and animal models of depression. These observations are linked to functional evidences, such as impairments in the cross-talk between glia and neurons, changes in the level of neurotransmitter or immunoactive substances, myelination status, and synapse formation, maintenance or elimination.pt_PT
dc.description.sponsorshipJO and LP received fellowships from the Foundation for Science and Technology (FCT) and their work is funded by FCT (SFRH/BD/101298/2014 to JO and IF/01079/2014 to LP) and Bial Foundation (207/14 for JO and 427/14 for LP) projects. SV is supported by FCT (SFRH/BPD/81627/2011). CG is supported by FCT (SFRH/BPD/63013/2009). This work was co-funded by the Life and Health Sciences Research Institute (ICVS), and Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (projects NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023). This work has been also funded by FEDER funds, through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the (FCT), under the scope of the project POCI-01-0145-FEDER-007038.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Cell Neurosci. 2016 Jun 17;10:163pt_PT
dc.identifier.doi10.3389/fncel.2016.00163pt_PT
dc.identifier.eissn1662-5102
dc.identifier.urihttp://hdl.handle.net/10451/49211
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationNORTE-01-0145-FEDER-000013pt_PT
dc.relationThe impact of neuron-astrocyte networks on cognitive function in depression
dc.relationPOCI-01-0145-FEDER-007038pt_PT
dc.relationMODULATION OF THE BIDIRECTIONAL COMMUNICATION BETWEEN NEURONS AND ASTROCYTES AT THE SYNAPSE: INFLUENCE OF BDNF AND P2 RECEPTORS
dc.relationINTERACTION BETWEEN ADENOSINE A2A RECEPTORS AND GROWTH FACTORS IN THE CONTROL OF NEURODEGENERATION AND BRAIN REPAIR
dc.relation.publisherversionhttps://www.frontiersin.org/journals/cellular-neurosciencept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAstrocytept_PT
dc.subjectDepressionpt_PT
dc.subjectGliapt_PT
dc.subjectMicrogliapt_PT
dc.subjectOligodendrocitespt_PT
dc.titleGlial plasticity in depressionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleThe impact of neuron-astrocyte networks on cognitive function in depression
oaire.awardTitleMODULATION OF THE BIDIRECTIONAL COMMUNICATION BETWEEN NEURONS AND ASTROCYTES AT THE SYNAPSE: INFLUENCE OF BDNF AND P2 RECEPTORS
oaire.awardTitleINTERACTION BETWEEN ADENOSINE A2A RECEPTORS AND GROWTH FACTORS IN THE CONTROL OF NEURODEGENERATION AND BRAIN REPAIR
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F101298%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01079%2F2014%2FCP1212%2FCT0017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F81627%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F63013%2F2009/PT
oaire.citation.titleFrontiers in Cellular Neurosciencept_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamPOR_NORTE
oaire.fundingStreamInvestigador FCT
person.familyNameHenriques Vaz
person.givenNameSandra Cristina
person.identifier.ciencia-id0E1C-952D-61BE
person.identifier.orcid0000-0003-4258-9397
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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