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Allele-specific expression variation at different ploidy levels in Squalius alburnoides

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dc.contributor.authorMatos, Isa
dc.contributor.authorMachado, Miguel P.
dc.contributor.authorSchartl, Manfred
dc.contributor.authorCoelho, Maria Manuela
dc.date.accessioned2021-12-10T15:11:24Z
dc.date.available2021-12-10T15:11:24Z
dc.date.issued2019
dc.description© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.pt_PT
dc.description.abstractAllopolyploid plants are long known to be subject to a homoeolog expression bias of varying degree. The same phenomenon was only much later suspected to occur also in animals based on studies of single selected genes in an allopolyploid vertebrate, the Iberian fish Squalius alburnoides. Consequently, this species became a good model for understanding the evolution of gene expression regulation in polyploid vertebrates. Here, we analyzed for the first time genome-wide allele-specific expression data from diploid and triploid hybrids of S. alburnoides and compared homoeolog expression profiles of adult livers and of juveniles. Co-expression of alleles from both parental genomic types was observed for the majority of genes, but with marked homoeolog expression bias, suggesting homoeolog specific reshaping of expression level patterns in hybrids. Complete silencing of one allele was also observed irrespective of ploidy level, but not transcriptome wide as previously speculated. Instead, it was found only in a restricted number of genes, particularly ones with functions related to mitochondria and ribosomes. This leads us to hypothesize that allelic silencing may be a way to overcome intergenomic gene expression interaction conflicts, and that homoeolog expression bias may be an important mechanism in the achievement of sustainable genomic interactions, mandatory to the success of allopolyploid systems, as in S. alburnoides.pt_PT
dc.description.sponsorshipThis work was funded by the strategic project UID/BIA/00329/2013 granted to cE3c and by a PhD grant (SFRH/BD/61217/2009) to IM, both from the Portuguese National Science Foundation, Fundação para a Ciência e a Tecnologia. The publication was funded by the German Research Foundation (DFG) and the University of Wuerzburg in the funding programme Open Access Publishing.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSci Rep. 2019 Mar 6;9(1):3688pt_PT
dc.identifier.doi10.1038/s41598-019-40210-8pt_PT
dc.identifier.eissn2045-2322
dc.identifier.urihttp://hdl.handle.net/10451/50340
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationREGULATION OF GENE EXPRESSION IN TRIPLOID VERTEBRATES
dc.relation.publisherversionhttps://www.nature.com/srep/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleAllele-specific expression variation at different ploidy levels in Squalius alburnoidespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleREGULATION OF GENE EXPRESSION IN TRIPLOID VERTEBRATES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIA%2F00329%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/PIDDAC/SFRH%2FBD%2F61217%2F2009/PT
oaire.citation.issue1pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume9pt_PT
oaire.fundingStream5876
oaire.fundingStreamPIDDAC
person.familyNameMatos
person.familyNameMachado
person.familyNameCoelho
person.givenNameIsa
person.givenNameMiguel
person.givenNameMaria
person.identifier.ciencia-id3A18-725E-8CBE
person.identifier.ciencia-id3A15-8A0A-6687
person.identifier.orcid0000-0002-3725-6742
person.identifier.orcid0000-0002-1786-8522
person.identifier.orcid0000-0003-3288-1693
person.identifier.ridF-6846-2015
person.identifier.ridB-8672-2009
person.identifier.scopus-author-id26643445100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8e111108-a309-4128-abf0-a6eec8a4a532
relation.isAuthorOfPublication3055d543-45c3-4f83-b394-c9aaac71bf4e
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relation.isAuthorOfPublication.latestForDiscovery7860e69a-e0a5-463c-9efb-ec522e35ea9d
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