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Three new jatrophane-type diterpenes from Euphorbia pubescens

2003Journal article Metadata only
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dc.contributor.authorValente, C
dc.contributor.authorFerreira, MJU
dc.contributor.authorAbreu, PM
dc.contributor.authorPedro, M
dc.contributor.authorCerqueira, F
dc.contributor.authorNascimento, MSJ
dc.date.accessioned2015-12-30T10:18:08Z
dc.date.available2015-12-30T10:18:08Z
dc.date.issued2003
dc.description.abstractThree new macrocyclic jatrophane diterpene polyesters, named pubescenes A (1), B (2), and C (3), and the known compounds indole-3-aldehyde and scopoletin have been isolated and characterised from the whole dried plant of Euphorbia pubescens. The structures of the new compounds were established by spectroscopic means including 2D-NMR techniques such as COSY, HMQC, HMBC and NOESY experiments. Compounds 1-3 were evaluated for their in vitro effect on the growth of three human cancer cell lines MCF-7 (breast), NCI-H460 (lung) and SF-268 (CNS) as well as for their capacity to interfere with the proliferation of human peripheral blood lymphocytes. They exhibited a moderate growth inhibitory effect on the cancer cell line NCI-H460. No effect was observed on the mitogenic response of human lymphocytes to PHA.
dc.formatapplication/pdf
dc.identifier.citationPLANTA MEDICA. - Vol. 69, n. 4 (APR 2003), p. 361-366
dc.identifier.issn0032-0943
dc.identifier.urihttp://hdl.handle.net/10451/21428
dc.language.isoeng
dc.publisherGEORG THIEME VERLAG KG
dc.subjectPlant Sciences
dc.subjectChemistry, Medicinal
dc.subjectPharmacology & Pharmacy
dc.titleThree new jatrophane-type diterpenes from Euphorbia pubescens
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage366por
oaire.citation.startPage361por
oaire.citation.titlePLANTA MEDICApor
oaire.citation.volumeVol. 69por
rcaap.rightsrestrictedAccess
rcaap.typearticle

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