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Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects

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dc.contributor.authorPires Barreira, David
dc.contributor.authorMarinho, Rui
dc.contributor.authorBicho, Manuel
dc.contributor.authorFlores, Isabel
dc.contributor.authorFialho, Renata
dc.contributor.authorOuakinin, Sílvia
dc.date.accessioned2019-11-05T16:05:53Z
dc.date.available2019-11-05T16:05:53Z
dc.date.issued2019
dc.descriptionCopyright © 2019 Barreira, Marinho, Bicho, Flores, Fialho and Ouakinin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractBackground: The hepatitis C virus (HCV) is known to infect the brain, however, the findings based on associated neuropsychiatric syndrome are controversial and the association itself remains unclear. Gender research in HCV infection is limited, failing to integrate the role of gender differences in neurocognitive syndrome. The aim of this study was to characterize psychological and neurocognitive profiles in HCV-infected patients before treatment and to explore gender differences in those profiles, as well as the impact of disease severity. Methods: A total of 86 patients diagnosed with chronic hepatitis C were included. Depression and anxiety were assessed using Hamilton anxiety scale (HAM-A), Hamilton depression scale (HAM-D), Beck Depression Inventory (BDI). For cognition, a neuropsychological battery to measure attention, concentration and memory was used, and executive function components validated for the Portuguese population was also used before starting treatment. To identify the disease severity, platelet ratio index, and FibroScan® were used. Results: A statistically significant gender effect was found on HAM-A (B = 0.64, CI: 0.17–1.11) and HAM-D (B = 0.62, CI: 0.14–1.09), with women scoring higher compared to men. Regarding neuropsychological scores, significant differences between gender were identified in executive functions measured by Trail Making Test (TMT B) (B = 0.48, CI: 0.02–0.97), TMT B-A (B = 0.26, CI: −39.2 to −3.7) and in digit span total (B = −0.52, CI: −1.0 to −0.04), with women performing worse than men. Controlling for years of substance dependence, TMT-B and TMT B-A showed significant gender differences. Regarding the presence or absence of substance dependence, only HAM-A and HAM-D remained significant. For categorical variables, Digit Span Total was also influenced by gender, with women being more likely to be impaired: odds ratio (OR) = 7.07, CI: 2.04–24.45), and a trend was observed for Digit Span Backward (OR = 3.57, CI: 1.31–9.75). No significant differences were found between disease severity and neurocognitive performance. Conclusion: Data suggest that gender has an influence on depression, anxiety and cognitive functions with women showing greater impairment compared with men. This effect seems to be influenced by substance dependence.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFrontiers in Psychology | October 2019 | Volume 10 | Article 2317pt_PT
dc.identifier.doi10.3389/fpsyg.2019.02317
dc.identifier.issn1664-1078
dc.identifier.urihttp://hdl.handle.net/10451/40079
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/journals/psychologypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHepatitis Cpt_PT
dc.subjectNeurocognitionpt_PT
dc.subjectAnxietypt_PT
dc.subjectDepressionpt_PT
dc.subjectGenderpt_PT
dc.subjectDisease severitypt_PT
dc.titleHepatitis C pretreatment profile and gender differences : cognition and disease severity effectspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage2317pt_PT
oaire.citation.titleFrontiers in Psychologypt_PT
oaire.citation.volume10pt_PT
person.familyNamePires Barreira
person.familyNameMarinho
person.familyNameBicho
person.familyNameOuakinin
person.givenNameDavid
person.givenNameRui
person.givenNameManuel
person.givenNameSílvia
person.identifier103277
person.identifier103095
person.identifier.ciencia-id931F-B799-E0F2
person.identifier.ciencia-id531A-BB6A-AA45
person.identifier.ciencia-id9512-8D22-1B28
person.identifier.orcid0000-0001-7273-8547
person.identifier.orcid0000-0003-1327-3537
person.identifier.orcid0000-0002-5773-5687
person.identifier.orcid0000-0002-2123-9104
person.identifier.scopus-author-id55915259900
person.identifier.scopus-author-id7005027284
person.identifier.scopus-author-id7004153755
person.identifier.scopus-author-id24339026700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication6b576d91-1f3b-4e5f-a8a9-235556906cb6
relation.isAuthorOfPublicationb842b032-ae00-453c-b774-b84ec4a09199
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relation.isAuthorOfPublication.latestForDiscoveryb842b032-ae00-453c-b774-b84ec4a09199

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