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A Novel Hybrid Nanosystem Integrating Cytotoxic and Magnetic Properties as a Tool to Potentiate Melanoma Therapy

2020Journal article Open access
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dc.contributor.authorCruz, Nuno
dc.contributor.authorPinho, Jacinta Oliveira
dc.contributor.authorSoveral, Graça
dc.contributor.authorAscensão, Lia
dc.contributor.authorMatela, Nuno
dc.contributor.authorReis, Catarina
dc.contributor.authorGaspar, Maria Manuela
dc.date.accessioned2025-03-13T17:39:38Z
dc.date.available2025-03-13T17:39:38Z
dc.date.issued2020
dc.description.abstractCancer is a major health concern and the prognosis is often poor. Significant advances in nanotechnology are now driving a revolution in cancer detection and treatment. The goal of this study was to develop a novel hybrid nanosystem for melanoma treatment, integrating therapeutic and magnetic targeting modalities. Hence, we designed long circulating and pH-sensitive liposomes loading both dichloro(1,10-phenanthroline) copper (II) (Cuphen), a cytotoxic metallodrug, and iron oxide nanoparticles (IONPs). The synthetized IONPs were characterized by transmission electron microscopy and dynamic light scattering. Lipid-based nanoformulations were prepared by the dehydration rehydration method, followed by an extrusion step for reducing and homogenizing the mean size. Liposomes were characterized in terms of incorporation parameters and mean size. High Cuphen loadings were obtained and the presence of IONPs slightly reduced Cuphen incorporation parameters. Cuphen antiproliferative properties were preserved after association to liposomes and IONPs (at 2 mg/mL) did not interfere on cellular proliferation of murine and human melanoma cell lines. Moreover, the developed nanoformulations displayed magnetic properties. The absence of hemolytic activity for formulations under study demonstrated their safety for parenteral administration. In conclusion, a lipid-based nanosystem loading the cytotoxic metallodrug, Cuphen, and displaying magnetic properties was successfully designed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/nano10040693pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/99306
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationFundação para a Ciência e a Tecnologia (FCT) grant number UID/DTP/04138/2019pt_PT
dc.relationFundação para a Ciência e a Tecnologia (FCT) grant number PTDC/BTM-SAL/28977/2017pt_PT
dc.relationFundação para a Ciência e a Tecnologia (FCT) grant number PTDC/MED-QUI/31721/2017pt_PT
dc.relationFundação para a Ciência e a Tecnologia (FCT) grant number UIDB/00645/2020pt_PT
dc.relationFundação para a Ciência e a Tecnologia (FCT) grant number SFRH/BD/117586/2016pt_PT
dc.relationFundação para a Ciência e a Tecnologia (FCT) grant number UID/AMB/50017/2019pt_PT
dc.subjectCuphenpt_PT
dc.subjectiron oxide nanoparticlespt_PT
dc.subjectpH-sensitive liposomespt_PT
dc.subjectmagnetic targetingpt_PT
dc.subjectmelanoma therapypt_PT
dc.subjectnanoparticles safetypt_PT
dc.titleA Novel Hybrid Nanosystem Integrating Cytotoxic and Magnetic Properties as a Tool to Potentiate Melanoma Therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPage693pt_PT
oaire.citation.titleNanomaterialspt_PT
oaire.citation.volume10pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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