Publication
Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
| dc.contributor.author | Soares, R. | |
| dc.contributor.author | Foxall, R. | |
| dc.contributor.author | Albuquerque, A. | |
| dc.contributor.author | Cortesão, C. | |
| dc.contributor.author | Garcia, M. | |
| dc.contributor.author | Victorino, R. M. | |
| dc.contributor.author | Sousa, A. E. | |
| dc.date.accessioned | 2015-02-03T16:46:43Z | |
| dc.date.available | 2015-02-03T16:46:43Z | |
| dc.date.issued | 2006 | |
| dc.description | © 2006, American Society for Microbiology. All Rights Reserved. | por |
| dc.description.abstract | CCR5 expression determines susceptibility to infection, cell tropism, and the rate of human immunodeficiency virus type 1 (HIV-1) disease progression. CCR5 is also considered the major HIV-2 coreceptor in vivo, in spite of broad coreceptor use in vitro. Here we report a significantly increased proportion of memory-effector CD4 T cells expressing CCR5 in HIV-2-infected patients correlating with CD4 depletion. Moreover, HIV-2 proviral DNA was essentially restricted to memory-effector CD4, suggesting that this is the main target for HIV-2. Similar levels of proviral DNA were found in the two infection categories. Thus, the reduced viremia and slow rate of CD4 decline that characterize HIV-2 infection seem to be unrelated to coreceptor availability. | eng |
| dc.description.sponsorship | This work was supported by grants from Fundação para a Ciência e a Tecnologia (FCT) and Comissão Nacional de Luta Contra a SIDA to A.E.S. R.S., R.F., and C.C. received scholarships from FCT. | por |
| dc.identifier.citation | Journal of Virology, Dec. 2006, Vol. 80, No. 24, p. 12425–12429 | por |
| dc.identifier.issn | 0022-538X | |
| dc.identifier.uri | http://dx.doi.org/ 10.1128/JVI.01557-06 | |
| dc.identifier.uri | http://hdl.handle.net/10451/15880 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | American Society for Microbiology | por |
| dc.relation.publisherversion | The definitive version is available at http://jvi.asm.org/ | por |
| dc.title | Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Journal of Virology | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |