Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection

Soares, R.; Foxall, R.; Albuquerque, A.; Cortesão, C.; Garcia, M.; Victorino, R. M.; Sousa, A. E.

http://hdl.handle.net/10451/15880

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Abstract(s)

CCR5 expression determines susceptibility to infection, cell tropism, and the rate of human immunodeficiency virus type 1 (HIV-1) disease progression. CCR5 is also considered the major HIV-2 coreceptor in vivo, in spite of broad coreceptor use in vitro. Here we report a significantly increased proportion of memory-effector CD4 T cells expressing CCR5 in HIV-2-infected patients correlating with CD4 depletion. Moreover, HIV-2 proviral DNA was essentially restricted to memory-effector CD4, suggesting that this is the main target for HIV-2. Similar levels of proviral DNA were found in the two infection categories. Thus, the reduced viremia and slow rate of CD4 decline that characterize HIV-2 infection seem to be unrelated to coreceptor availability.