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Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery: a systematic review and meta-analysis

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dc.contributor.authorRibeiro, Gabriela
dc.contributor.authorMaia, Ana
dc.contributor.authorCotovio, Gonçalo
dc.contributor.authorOliveira, Francisco P. M.
dc.contributor.authorCosta, Durval C.
dc.contributor.authorOliveira-Maia, Albino J.
dc.date.accessioned2023-03-28T14:39:31Z
dc.date.available2023-03-28T14:39:31Z
dc.date.issued2023
dc.description© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.pt_PT
dc.description.abstractThere is significant evidence linking a 'reward deficiency syndrome' (RDS), comprising decreased availability of striatal dopamine D2-like receptors (DD2lR) and addiction-like behaviors underlying substance use disorders and obesity. Regarding obesity, a systematic review of the literature with a meta-analysis of such data is lacking. Following a systematic review of the literature, we performed random-effects meta-analyses to determine group differences in case-control studies comparing DD2lR between individuals with obesity and non-obese controls and prospective studies of pre- to post-bariatric surgery DD2lR changes. Cohen's d was used to measure effect size. Additionally, we explored factors potentially associated with group differences in DD2lR availability, such as obesity severity, using univariate meta-regression. In a meta-analysis including positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies, striatal DD2lR availability did not significantly differ between obesity and controls. However, in studies comprising patients with class III obesity or higher, group differences were significant, favoring lower DD2lR availability in the obesity group. This effect of obesity severity was corroborated by meta-regressions showing inverse associations between the body mass index (BMI) of the obesity group and DD2lR availability. Post-bariatric changes in DD2lR availability were not found, although a limited number of studies were included in this meta-analysis. These results support lower DD2lR in higher classes of obesity which is a more targeted population to explore unanswered questions regarding the RDS.pt_PT
dc.description.sponsorshipAJO-M was supported by grants PTDC/MED-NEU/31331/2017 from Fundação para a Ciência e Tecnologia (FCT), and a Starting Grant from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No. 950357). GR was funded by doctoral fellowships from Universidade de Lisboa (BD/2015Call) and FCT (SFRH/BD/128783/2017). AM and GC were supported by doctoral fellowships from FCT (SFRH/BD/144508/2019; SFRH/BD/130210/2017).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSci Rep. 2023 Mar 27;13(1):4959pt_PT
dc.identifier.doi10.1038/s41598-023-31250-2pt_PT
dc.identifier.eissn2045-2322
dc.identifier.urihttp://hdl.handle.net/10451/56876
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationPTDC/MED-NEU/31331/2017pt_PT
dc.relation950357pt_PT
dc.relationSFRH/BD/128783/2017pt_PT
dc.relationImmune dysfunction in obsessive-compulsive disorder: from environmental risk factors to clinical and brain imaging correlates
dc.relationAntidepressant mechanisms of psilocybin: from cortical excitability to brain functional connectivity
dc.relation.publisherversionhttps://www.nature.com/srep/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleStriatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery: a systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/BD/144508/2019
oaire.awardNumberSFRH/BD/130210/2017
oaire.awardTitleImmune dysfunction in obsessive-compulsive disorder: from environmental risk factors to clinical and brain imaging correlates
oaire.awardTitleAntidepressant mechanisms of psilocybin: from cortical excitability to brain functional connectivity
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F144508%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F130210%2F2017/PT
oaire.citation.issue1pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume13pt_PT
oaire.fundingStreamOE
person.familyNameRibeiro
person.givenNameGabriela
person.identifier628029
person.identifier.ciencia-idE615-EE57-0F84
person.identifier.orcid0000-0002-2232-0115
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8caa0f6c-f40c-4946-8df2-a2658843ea36
relation.isAuthorOfPublication.latestForDiscovery8caa0f6c-f40c-4946-8df2-a2658843ea36
relation.isProjectOfPublication76a69a02-52af-4925-9a0d-4f7d50859453
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