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PD-1 and ICOS are coexpressed in T follicular helper cells but define three stages of maturation of T follicular regulatory cells

2025Journal article Open access
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dc.contributor.authorRibeiro, Filipa
dc.contributor.authorAntunes, Diogo
dc.contributor.authorPires, Ana R.
dc.contributor.authorRino, José
dc.contributor.authorFilipe, Beatriz
dc.contributor.authorJesus, Kátia
dc.contributor.authorCorreia, Ricardo
dc.contributor.authorFonseca, Válter R
dc.contributor.authorKumar, Saumya
dc.contributor.authorGraca, Luis
dc.date.accessioned2025-07-31T11:32:05Z
dc.date.available2025-07-31T11:32:05Z
dc.date.issued2025
dc.descriptionCopyright © 2025 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).pt_PT
dc.description.abstractHumoral responses to infection or vaccination require T cell-B cell interactions. T follicular helper (TFH) cells drive germinal center (GC) responses by providing help to B cells, whereas T follicular regulatory (TFR) cells regulate them. Both mature GC-located TFH and TFR cells are widely characterized by the expression of ICOS and PD-1. However, although human TFR cells share many phenotypic characteristics with TFH cells, we found that ICOS and PD-1 are up-regulated differently in each. Although TFH cells express these proteins synchronously during maturation, they define three maturation stages in TFR cells. TFR cells in an intermediate maturation stage express ICOS, and it is only at the last stage of differentiation that both molecules are expressed at high levels. Although most TFR cells within the B cell follicle are PD-1-, the TFR within the GC are ICOS+PD-1+. These results show that TFH and TFR cells within human lymphoid tissue follow distinct maturation stages.pt_PT
dc.description.sponsorshipThis work was supported by the Fundacion la Caixa grant HR22-00741 and the Portuguese Fundação para a Ciência e Tecnologia (FCT) grant 2022.04903.PTDC to L.G.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSci Adv. 2025 Jul 11;11(28):eadt8901pt_PT
dc.identifier.doi10.1126/sciadv.adt8901pt_PT
dc.identifier.eissn2375-2548
dc.identifier.urihttp://hdl.handle.net/10400.5/102588
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Association for the Advancement of Sciencept_PT
dc.relationModulation of human antibody responses by T follicular helper subsets
dc.relation.publisherversionhttps://www.science.org/journal/sciadvpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titlePD-1 and ICOS are coexpressed in T follicular helper cells but define three stages of maturation of T follicular regulatory cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleModulation of human antibody responses by T follicular helper subsets
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022/2022.04903.PTDC/PT
oaire.citation.issue28pt_PT
oaire.citation.titleScience Advancespt_PT
oaire.citation.volume11pt_PT
oaire.fundingStreamConcurso de Projetos de I&D em Todos os Domínios Científicos - 2022
person.familyNameRibeiro
person.familyNameAntunes
person.familyNamePires
person.familyNameRino Henriques
person.familyNameGuerreiro Filipe
person.familyNameRibeiro de Jesus
person.familyNamePires Correia
person.familyNameFonseca
person.familyNameKumar
person.familyNameSilva Graca
person.givenNameFilipa
person.givenNameDiogo
person.givenNameAna R.
person.givenNameJosé Miguel
person.givenNameBeatriz
person.givenNameKátia
person.givenNameRicardo Jorge
person.givenNameValter
person.givenNameSaumya
person.givenNameLuis Ricardo
person.identifierB-8887-2008
person.identifier.ciencia-id921E-0E21-9DFC
person.identifier.ciencia-idA117-FBDB-A27B
person.identifier.ciencia-id751A-76EE-E53F
person.identifier.ciencia-id6111-8798-8AAA
person.identifier.ciencia-id1B1F-BD57-821A
person.identifier.ciencia-idD511-03C9-4CF3
person.identifier.ciencia-id6C19-B162-F561
person.identifier.orcid0000-0001-7665-3436
person.identifier.orcid0000-0002-7929-9142
person.identifier.orcid0000-0002-0536-7333
person.identifier.orcid0000-0002-0637-4527
person.identifier.orcid0000-0002-0928-3751
person.identifier.orcid0000-0001-5180-7566
person.identifier.orcid0009-0006-2502-8298
person.identifier.orcid0000-0001-6707-8011
person.identifier.orcid0000-0001-9481-1944
person.identifier.orcid0000-0001-6935-8500
person.identifier.scopus-author-id36138488700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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