Logo do repositório
 
Publicação

Unzippers, resolvers and sensors: a structural and functional biochemistry tale of RNA helicases

2015Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorLeitão, Ana
dc.contributor.authorCosta, Marina C.
dc.contributor.authorEnguita, Francisco J.
dc.date.accessioned2022-03-14T16:52:31Z
dc.date.available2022-03-14T16:52:31Z
dc.date.issued2015
dc.description© 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractThe centrality of RNA within the biological world is an irrefutable fact that currently attracts increasing attention from the scientific community. The panoply of functional RNAs requires the existence of specific biological caretakers, RNA helicases, devoted to maintain the proper folding of those molecules, resolving unstable structures. However, evolution has taken advantage of the specific position and characteristics of RNA helicases to develop new functions for these proteins, which are at the interface of the basic processes for transference of information from DNA to proteins. RNA helicases are involved in many biologically relevant processes, not only as RNA chaperones, but also as signal transducers, scaffolds of molecular complexes, and regulatory elements. Structural biology studies during the last decade, founded in X-ray crystallography, have characterized in detail several RNA-helicases. This comprehensive review summarizes the structural knowledge accumulated in the last two decades within this family of proteins, with special emphasis on the structure-function relationships of the most widely-studied families of RNA helicases: the DEAD-box, RIG-I-like and viral NS3 classes.pt_PT
dc.description.sponsorshipMarina C. Costa was supported by a post-doctoral fellowship from Fundação para a Ciência e Tecnologia, Portugal (Ref. SFRH/BPD/65131/2009).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Mol Sci. 2015 Jan 22;16(2):2269-2293pt_PT
dc.identifier.doi10.3390/ijms16022269pt_PT
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10451/51736
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationE-SMART: ENGINEERING OF MIRNA TARGET SITES IN CODING TRANSCRIPTS
dc.relation.publisherversionhttps://www.mdpi.com/journal/ijmspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectRNA helicasept_PT
dc.subjectStructural biologypt_PT
dc.subjectProtein-RNA complexpt_PT
dc.subjectDEAD-box proteinpt_PT
dc.subjectInnate immunitypt_PT
dc.subjectRIG-Ipt_PT
dc.titleUnzippers, resolvers and sensors: a structural and functional biochemistry tale of RNA helicasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/BPD/65131/2009
oaire.awardTitleE-SMART: ENGINEERING OF MIRNA TARGET SITES IN CODING TRANSCRIPTS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F65131%2F2009/PT
oaire.citation.endPage2293pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage2269pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume16pt_PT
person.familyNameCosta
person.familyNameEnguita
person.givenNameMarina
person.givenNameFrancisco J.
person.identifier173306
person.identifier.ciencia-id6818-7810-6CEC
person.identifier.ciencia-idB215-8D49-3218
person.identifier.orcid0000-0001-9020-7539
person.identifier.orcid0000-0002-8072-8557
person.identifier.ridO-1710-2014
person.identifier.ridA-2347-2009
person.identifier.scopus-author-id55453276400
person.identifier.scopus-author-id6602119231
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc4dcab9e-b873-4587-bb30-5203af150404
relation.isAuthorOfPublicationa101dbd4-6bf5-4546-882e-e2596eddb6b4
relation.isAuthorOfPublication.latestForDiscoveryc4dcab9e-b873-4587-bb30-5203af150404
relation.isProjectOfPublication404c868f-1b7d-402a-869d-09c41b4817da
relation.isProjectOfPublication.latestForDiscovery404c868f-1b7d-402a-869d-09c41b4817da

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Unzippers_resolvers.pdf
Tamanho:
12.11 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

IMM - Artigos em Revistas Internacionais
FM - Artigos em Revistas Internacionais