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Collagen biology making inroads into prognosis and treatment of cancer progression and metastasis

2020Journal article Restricted access
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dc.contributor.authorMartins Cavaco, Ana C.
dc.contributor.authorDâmaso, Sara
dc.contributor.authorCasimiro, Sandra
dc.contributor.authorCosta, Luis
dc.date.accessioned2022-09-23T12:56:43Z
dc.date.available2022-09-23T12:56:43Z
dc.date.issued2020
dc.description© Springer Science+Business Media, LLC, part of Springer Nature 2020pt_PT
dc.description.abstractProgression through dissemination to tumor-surrounding tissues and metastasis development is a hallmark of cancer that requires continuous cell-to-cell interactions and tissue remodeling. In fact, metastization can be regarded as a tissue disease orchestrated by cancer cells, leading to neoplastic colonization of new organs. Collagen is a major component of the extracellular matrix (ECM), and increasing evidence suggests that it has an important role in cancer progression and metastasis. Desmoplasia and collagen biomarkers have been associated with relapse and death in cancer patients. Despite the increasing interest in ECM and in the desmoplastic process in tumor microenvironment as prognostic factors and therapeutic targets in cancer, further research is required for a better understanding of these aspects of cancer biology. In this review, published evidence correlating collagen with cancer prognosis is retrieved and analyzed, and the role of collagen and its fragments in cancer pathophysiology is discussed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCancer Metastasis Rev. 2020 Sep;39(3):603-623pt_PT
dc.identifier.doi10.1007/s10555-020-09888-5pt_PT
dc.identifier.eissn1573-7233
dc.identifier.issn0167-7659
dc.identifier.urihttp://hdl.handle.net/10451/54561
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.springer.com/journal/10555pt_PT
dc.subjectBiologic functionspt_PT
dc.subjectCancerpt_PT
dc.subjectCollagenpt_PT
dc.subjectCollagen fragmentspt_PT
dc.subjectDesmoplasiapt_PT
dc.subjectPrognostic toolspt_PT
dc.titleCollagen biology making inroads into prognosis and treatment of cancer progression and metastasispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage623pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage603pt_PT
oaire.citation.titleCancer and Metastasis Reviewspt_PT
oaire.citation.volume39pt_PT
person.familyNameCara de Anjo Casimiro
person.familyNameCosta
person.givenNameSandra Cristina
person.givenNameLuis
person.identifier.ciencia-id0F12-5181-0B22
person.identifier.ciencia-id041E-4ADE-FB64
person.identifier.orcid0000-0002-6917-4477
person.identifier.orcid0000-0002-4782-7318
person.identifier.scopus-author-id14043403400
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfd665de1-a7e6-4638-94c3-ecc645f84607
relation.isAuthorOfPublication8a2ab4c6-ba86-4433-b4b7-6256d81890e5
relation.isAuthorOfPublication.latestForDiscovery8a2ab4c6-ba86-4433-b4b7-6256d81890e5

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