Repository logo
 
Publication

Metabolically healthy overweight adolescents : definition and components

2020Journal article Open access
Simple item page
dc.contributor.authorVideira-Silva, Antonio
dc.contributor.authorFreira, Silvia
dc.contributor.authorFonseca, Helena
dc.date.accessioned2021-02-02T13:21:12Z
dc.date.available2021-02-02T13:21:12Z
dc.date.issued2020
dc.description© 2020 Annals of Pediatric Endocrinology & Metabolism. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly citedpt_PT
dc.description.abstractPurpose: In adolescents, the definition and clinical implications of metabolically healthy overweight (MHO) status have not been established. This study aimed to investigate the prevalence of MHO according to its most widespread definition, which is based on metabolic syndrome (MS), and to explore further metabolic indicators such as Homeostatic Model Assessment of Insulin Resistance, total cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, and C-reactive protein levels, together with metabolic health predictors in a sample of adolescents attending a pediatric obesity clinic. Methods: Data from 487 adolescents categorized as overweight (52.6% females, 88.1% white), with a mean body mass index (BMI) z-score of 2.74 (±1.07 standard deviation [SD]), and a mean age of 14.4 years (±2.2 SD) were cross-sectionally analyzed. From this original sample, a subsample of 176 adolescents underwent a second assessment at 12 (±6 SD) months for longitudinal analysis. Results: From the 487 adolescents originally analyzed, 200 (41.1%) were categorized as MHO, but only 93 (19.1%) had none of the metabolic indicators considered in this study. According to longitudinal analysis, 30 of the 68 adolescents (44%) categorized as MHO at baseline became non-MHO over time. BMI z-score was the best predictor of metabolic health both in cross-sectional and longitudinal analyses. Increased BMI z-score reduced the odds of being categorized as MHO (odds ratio [OR], 0.6; 95% confidence interval [CI], 0.4–0.9; P=.008) and increased the odds of having hypertension (OR 2.1, 95% CI: 1.4–3.3, P=0.001), insulin resistance (OR, 2.4; 95% CI, 1.4–4.1, P=0.001), or a proinflammatory state (OR, 1.2; 95% CI, 1.1–1.3, P=0.002). Conclusion: Diagnosis of MHO should not be exclusively based on MS parameters, and other metabolic indicators should be considered. Adolescents categorized as overweight should participate in weight-management lifestyle interventions regardless of their metabolic health phenotype.pt_PT
dc.description.sponsorshipAVS is supported by the Portuguese Foundation for Science and Technology (SFRH/BD/130193/2017)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAnn Pediatr Endocrinol Metab 2020;25:256-264pt_PT
dc.identifier.doi10.6065/apem.2040052.026pt_PT
dc.identifier.eissn2287-1292
dc.identifier.issn2287-1012
dc.identifier.urihttp://hdl.handle.net/10451/46119
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherKorean Society of Pediatric Endocrinologypt_PT
dc.relationThe effect of a physical activity consultation in the management of adolescent overweight, including anthropometry, physical activity levels, cardiorespiratory fitness, and endothelial health
dc.relation.publisherversionhttps://e-apem.org/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAdolescentspt_PT
dc.subjectOverweightpt_PT
dc.subjectWeight managementpt_PT
dc.subjectMetabolic healthpt_PT
dc.subjectMetabolic syndromept_PT
dc.titleMetabolically healthy overweight adolescents : definition and componentspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleThe effect of a physical activity consultation in the management of adolescent overweight, including anthropometry, physical activity levels, cardiorespiratory fitness, and endothelial health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F130193%2F2017/PT
oaire.citation.endPage264pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage256pt_PT
oaire.citation.titleAnnals of Pediatric Endocrinology & Metabolismpt_PT
oaire.citation.volume25pt_PT
oaire.fundingStreamOE
person.familyNameVideira Silva
person.familyNameFreira
person.familyNameFonseca
person.givenNameAntonio
person.givenNameSilvia
person.givenNameHelena
person.identifier.ciencia-idDD12-3E66-20BB
person.identifier.ciencia-id3F17-A0D4-D0C6
person.identifier.orcid0000-0002-8209-1676
person.identifier.orcid0000-0002-9068-7824
person.identifier.orcid0000-0003-0565-1403
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3aa7bf17-683a-4293-b91c-6f31d56ab463
relation.isAuthorOfPublication7d31fd3b-cc90-4a0a-bb4f-ca69e138c3f7
relation.isAuthorOfPublicationf4765445-af43-4a33-b056-4489e86ccc42
relation.isAuthorOfPublication.latestForDiscovery3aa7bf17-683a-4293-b91c-6f31d56ab463
relation.isProjectOfPublication267afb4d-710d-4088-ba34-e67a39970594
relation.isProjectOfPublication.latestForDiscovery267afb4d-710d-4088-ba34-e67a39970594

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Overweight_adolescents.pdf
Size:
314 KB
Format:
Adobe Portable Document Format
Download

Collections

FM-CUP-Artigos em Revistas Internacionais
IMM - Artigos em Revistas Internacionais