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Toxicological assessment of seven unregulated drinking water Disinfection By-products (DBPs) using the zebrafish embryo bioassay

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dc.contributor.authorChaves, Raquel S.
dc.contributor.authorGuerreiro, Catarina Sousa
dc.contributor.authorCardoso, Vítor V.
dc.contributor.authorBenoliel, Maria J.
dc.contributor.authorSantos, Miguel M.
dc.date.accessioned2020-07-21T11:51:23Z
dc.date.available2020-07-21T11:51:23Z
dc.date.issued2020
dc.description© 2020 Elsevier B.V. All rights reserved.pt_PT
dc.description.abstractDisinfection By-products (DBPs) are formed during the chemical treatment of water for human consumption, by the reaction of raw water with chemical agents used in the different steps of the process. Disinfection is one of the most important steps, inactivating pathogens and preventing their regrowth during water distribution. However, it is also involved in DBPs formation due to the use of disinfectant agents, such as chlorine, which reacts with dissolved precursors, such as pharmaceuticals, toxins, pesticides, among others. Given their widespread occurrence, potential human health and (eco) toxicological impacts are of particular interest due to their potential carcinogenicity and various non-carcinogenic effects, such as endocrine disruption. In this study, the developmental toxicity of chemically- different unregulated DBPs was evaluated using zebrafish embryo bioassay. Embryos were exposed to different concentrations of the target DBPs and multiple endpoints, including, mortality, morphological abnormalities and locomotor behavior were assessed at specific developmental stages (24, 48, 72 and 96 hpf). The different families of DBPs tested included nitrosamines, aldehydes, alcohols and ketones. The results show that the effects were compound dependent, with EC10 values varying between 0.04 mg/L (2-ethyl-1-hexanal) to 9.2 mg/L (hexachloroacetone). Globally, several of the tested unregulated DBPs displayed higher toxicity when compared with the available data for some already regulated, such as trihalomethanes (THMs), which highlights the importance of screening the toxicity of still untested and poorly characterized DBPs.pt_PT
dc.description.sponsorshipThis work was supported by FCT- Fundação Ciência e Tecnologia (grant PDE/BDE/122649/2016) and by the project NorWater - Poluentes emergentes nas águas da Galiza-Norte de Portugal: novas ferramentas para gestão de risco (Reference: 0725_NOR_WATER_1_P), financed by “Programa de Cooperação Interreg Portugal/Espanha, (POCTEP) 2014-2020.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationScience of the Total Environment 742 (2020) 140522pt_PT
dc.identifier.doi10.1016/j.scitotenv.2020.140522pt_PT
dc.identifier.eissn1879-1026
dc.identifier.issn0048-9697
dc.identifier.urihttp://hdl.handle.net/10451/44079
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationRisk Assessment of Disinfection Byproducts in Drinking Water Bioactivity detection of new ribosomal peptides produced by cyanobacterial strains
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/science-of-the-total-environmentpt_PT
dc.subjectRisk assessmentpt_PT
dc.subjectHuman healthpt_PT
dc.subjectDrinking waterpt_PT
dc.subjectEmerging contaminantpt_PT
dc.subjectWater treatment plantpt_PT
dc.subjectWater qualitypt_PT
dc.titleToxicological assessment of seven unregulated drinking water Disinfection By-products (DBPs) using the zebrafish embryo bioassaypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPDE/BDE/122649/2016
oaire.awardTitleRisk Assessment of Disinfection Byproducts in Drinking Water Bioactivity detection of new ribosomal peptides produced by cyanobacterial strains
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PDE%2FBDE%2F122649%2F2016/PT
oaire.citation.startPage140522pt_PT
oaire.citation.titleScience of the Total Environmentpt_PT
oaire.citation.volume742pt_PT
person.familyNameChaves
person.familyNamesousa guerreiro
person.givenNameRaquel
person.givenNamecatarina
person.identifier.ciencia-id4A1A-79C0-2F0D
person.identifier.ciencia-id311F-89E5-532C
person.identifier.orcid0000-0002-7118-1465
person.identifier.orcid0000-0002-8730-6517
person.identifier.scopus-author-id57209010126
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication5e83d1ec-300b-4499-85d4-43c22feb0020
relation.isAuthorOfPublicationcd573b0e-731c-474b-b158-6d9cf011289b
relation.isAuthorOfPublication.latestForDiscovery5e83d1ec-300b-4499-85d4-43c22feb0020
relation.isProjectOfPublication91ae6585-3d83-46fc-ab2c-cfeefc9b6c92
relation.isProjectOfPublication.latestForDiscovery91ae6585-3d83-46fc-ab2c-cfeefc9b6c92

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