Publication
Squaric acid: a valuable scaffold for developing antimalarials?
| dc.contributor.author | Kumar, S. Praveen | |
| dc.contributor.author | Glória, Paulo M. C. | |
| dc.contributor.author | Gonçalves, Lídia M. | |
| dc.contributor.author | Gut, Jiri | |
| dc.contributor.author | Rosenthal, Philip J. | |
| dc.contributor.author | Moreira, Rui | |
| dc.contributor.author | Santos, Maria M. M. | |
| dc.date.accessioned | 2013-12-05T16:16:23Z | |
| dc.date.available | 2013-12-05T16:16:23Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | We describe here the synthesis of a library of thirty-eight squaric derivatives and the evaluation of activity against papain-, falcipain-2- and a chloroquine-resistant strain of P. falciparum. The most active compounds combine significant antiplasmodial activity with minimal cytotoxicity. | por |
| dc.description.sponsorship | This work was supported by Fundação para a Ciência e a Tecnologia (Portugal) through postdoctoral fellowships to P.M.C.G. and S.P.K. and grant PEst-OE/SAU/UI4013/2011. We also thank Fundação para a Ciência e a Tecnologia (Portugal) for the project REDE/1518/REM/2005 for the mass experiments at LCLEM, Faculdade de Farmácia da Universidade de Lisboa. PJR is a Distinguished Clinical Scientist of the Doris Duke Charitable Foundation. | por |
| dc.identifier.citation | Med. Chem. Commun., 2012, 3, 489 | por |
| dc.identifier.issn | 2040-2503 | |
| dc.identifier.issn | 2040-2511 | |
| dc.identifier.uri | http://dx.doi.org/10.1039/c2md20011b | |
| dc.identifier.uri | http://hdl.handle.net/10451/9635 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.relation.publisherversion | http://pubs.rsc.org/en/content/articlepdf/2012/md/c2md20011b | por |
| dc.title | Squaric acid: a valuable scaffold for developing antimalarials? | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Cambridge | por |
| oaire.citation.endPage | 493 | por |
| oaire.citation.startPage | 489 | por |
| oaire.citation.title | Med. Chem. Commun | por |
| oaire.citation.volume | 3 | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |