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Squaric acid: a valuable scaffold for developing antimalarials?
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We describe here the synthesis of a library of thirty-eight squaric derivatives and the evaluation of activity against papain-, falcipain-2- and a chloroquine-resistant strain of P. falciparum. The most active compounds combine significant antiplasmodial activity with minimal cytotoxicity.
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Med. Chem. Commun., 2012, 3, 489