Logo do repositório
 
Publicação

Epidemic history of hepatitis C virus genotypes and subtypes in Portugal

2018Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorPalladino, Claudia
dc.contributor.authorEzeonwumelu, Ifeanyi Jude
dc.contributor.authorMarcelino, Rute
dc.contributor.authorBriz, Verónica
dc.contributor.authorMoranguinho, Inês
dc.contributor.authorSerejo, Fátima
dc.contributor.authorVelosa, José Fernando
dc.contributor.authorMarinho, Rui Tato
dc.contributor.authorBorrego, Pedro
dc.contributor.authorTaveira, Nuno
dc.date.accessioned2023-09-08T15:42:29Z
dc.date.available2023-09-08T15:42:29Z
dc.date.issued2018
dc.description.abstractAny successful strategy to prevent and control HCV infection requires an understanding of the epidemic behaviour among the different genotypes. Here, we performed the first characterization of the epidemic history and transmission dynamics of HCV subtypes in Portugal. Direct sequencing of NS5B was performed on 230 direct-acting antiviral drugs (DAA)-treatment naïve patients in Lisbon. Phylogenetic analysis was used for subtyping and transmission cluster identification. Bayesian methods were used to reconstruct the epidemic history of HCV subtypes. Sequences were analysed for resistance-associated substitutions (RAS). The majority of strains were HCV-GT1 (62.6%), GT3 (18.3%, all subtype 3a) and GT4 (16.1%). Among GT1, the most frequent were subtypes 1a (75.5%) and 1b (24.5%). Polyphyletic patterns were found in all but 12 lineages suggesting multiple introductions of the different subtypes in this population. Five distinct epidemics were identified. The first significant HCV epidemic in Portugal occurred between 1930s and 1960s, was caused almost exclusively by GT1b and was likely associated with blood transfusions. Rapid expansion of GT3a occurred in the 1960s and GT1a in the 1980s, associated with intravenous drug use. The most recent epidemics were caused by GT4a and GT4d and seem to be associated with the resurgence of opioid use. The C316N substitution was found in 31.4% of GT1b-patients. Close surveillance of patients bearing this mutation and undergoing dasabuvir-based regimens will be important to determine its impact on treatment outcome.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1038/s41598-018-30528-0pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/28489
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationEPIDEMIOLOGY, PATHOGENESIS AND DETERMINANTS OF HIV-1 TRANSMISSION AND DISEASE PROGRESSION IN THE ANGOLAN PERINATAL HIV COHORT APEHC
dc.relationGene therapy for HIV cure using RNA replicons.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleEpidemic history of hepatitis C virus genotypes and subtypes in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEPIDEMIOLOGY, PATHOGENESIS AND DETERMINANTS OF HIV-1 TRANSMISSION AND DISEASE PROGRESSION IN THE ANGOLAN PERINATAL HIV COHORT APEHC
oaire.awardTitleGene therapy for HIV cure using RNA replicons.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F77448%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F131062%2F2017/PT
oaire.citation.issue1pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume8pt_PT
oaire.fundingStreamOE
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication5c32faa6-8a9f-4fd4-b3a7-fa871a159d96
relation.isProjectOfPublication250af1fe-5815-4cce-8995-b19152bab737
relation.isProjectOfPublication.latestForDiscovery250af1fe-5815-4cce-8995-b19152bab737

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Epidemic history of hepatitis Cvirus genotypes and subtypes in Portugal.pdf
Tamanho:
2.12 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

ISCSP - Artigos em Revistas Internacionais