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Pediatric long Covid
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Long-COVID é uma entidade multissistémica relativamente bem descrita em adultos. No entanto, não é isso que que se verifica na população pediátrica. Considerando que nos encontramos perante uma pandemia, é muito importante conhecer e compreender as possíveis sequelas a longo prazo da COVID-19 nas crianças, no sentido de evitar erros de diagnóstico e fornecer o tratamento mais adequado possível.
Neste estudo foi realizada uma revisão da literatura sobre Long COVID em idade pediátrica, com o objetivo de compreender a sua prevalência e os principais sintomas associados à doença. Isso foi alcançado através de pesquisa de estudos observacionais na plataforma MEDLINE, por meio da interface PubMed, e MedxRiv. Os estudos incluídos foram avaliados utilizando o modelo SPIDER. Foram incluídos na nossa revisão quinze estudos. A prevalência de Long COVID variou entre 6,7% to 70%, tendo sido difícil de avaliar devido à heterogeneidade dos estudos. Na maioria dos estudos com controlo, foi observada uma menor prevalência de sintomas quando comparados os dois grupos, com dois estudos a relatar uma maior prevalência de sintomas persistentes no grupo de controlo, o que demonstra que os sintomas a longo prazo associados à infeção por SARS-CoV-2 podem ser difíceis de distinguir dos sintomas relacionados com a pandemia. No entanto, após a revisão dos estudos selecionados, podemos concluir que a Long COVID também está presente nas crianças e adolescentes, mas são necessários mais estudos para compreender melhor sua verdadeira prevalência.
Long-COVID is a relatively well-described multisystem disease in adults. However, that is not the case for the pediatric population. In the context of this pandemic, it is very important to know and understand the possible long-term sequelae of COVID in children, to assure there are no misdiagnosis, in order to provide proper treatment. This study represents a review on the literature found on long-COVID in the pediatric age, with the aim to understand it’s prevalence and the main symptoms associated with the disease. This was achieved by searching for observational studies in the MEDLINE platform, through the PubMed interface, and MedxRiv. We fully evaluated included articles using the SPIDER model. We included in our review fifteen studies. The most common symptoms reported were fatigue/tiredness, headaches, concentration/attention impairment, anosmia and ageusia, sleeping difficulties and shortness of breath. The prevalence of long COVID was difficult to assess due to the heterogeneity of the studies, varying from 6,7% to 70%. The majority of the controlled studies reported a lower prevalence of persisting symptoms when the study and control groups were compared, with two studies reporting a higher prevalence of symptoms in the control group. This highlights that long-term symptoms associated with SARS-CoV-2 infection may be difficult to distinguish from pandemic-related symptoms. Nevertheless, we found evidence that long COVID it’s also present in children, but further studies are needed in order to better understand it’s true prevalence.
Long-COVID is a relatively well-described multisystem disease in adults. However, that is not the case for the pediatric population. In the context of this pandemic, it is very important to know and understand the possible long-term sequelae of COVID in children, to assure there are no misdiagnosis, in order to provide proper treatment. This study represents a review on the literature found on long-COVID in the pediatric age, with the aim to understand it’s prevalence and the main symptoms associated with the disease. This was achieved by searching for observational studies in the MEDLINE platform, through the PubMed interface, and MedxRiv. We fully evaluated included articles using the SPIDER model. We included in our review fifteen studies. The most common symptoms reported were fatigue/tiredness, headaches, concentration/attention impairment, anosmia and ageusia, sleeping difficulties and shortness of breath. The prevalence of long COVID was difficult to assess due to the heterogeneity of the studies, varying from 6,7% to 70%. The majority of the controlled studies reported a lower prevalence of persisting symptoms when the study and control groups were compared, with two studies reporting a higher prevalence of symptoms in the control group. This highlights that long-term symptoms associated with SARS-CoV-2 infection may be difficult to distinguish from pandemic-related symptoms. Nevertheless, we found evidence that long COVID it’s also present in children, but further studies are needed in order to better understand it’s true prevalence.
Descrição
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2022
Palavras-chave
COVID-19 Long-COVID Coronavírus Crianças Crónica Pediatria