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Outcomes of cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia after the acute phase

2022Artigo científico Acesso aberto
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dc.contributor.authorvan de Munckhof, Anita
dc.contributor.authorLindgren, Erik
dc.contributor.authorKleinig, Timothy J.
dc.contributor.authorField, Thalia S.
dc.contributor.authorCordonnier, Charlotte
dc.contributor.authorKrzywicka, Katarzyna
dc.contributor.authorPoli, Sven
dc.contributor.authorSánchez van Kammen, Mayte
dc.contributor.authorBorhani-Haghighi, Afshin
dc.contributor.authorLemmens, Robin
dc.contributor.authorScutelnic, Adrian
dc.contributor.authorCiccone, Alfonso
dc.contributor.authorGattringer, Thomas
dc.contributor.authorWittstock, Matthias
dc.contributor.authorDizonno, Vanessa
dc.contributor.authorDevroye, Annemie
dc.contributor.authorElkady, Ahmed
dc.contributor.authorGünther, Albrecht
dc.contributor.authorCervera, Alvaro
dc.contributor.authorMengel, Annerose
dc.contributor.authorChew, Beng Lim Alvin
dc.contributor.authorBuck, Brian
dc.contributor.authorZanferrari, Carla
dc.contributor.authorGarcia-Esperon, Carlos
dc.contributor.authorJacobi, Christian
dc.contributor.authorSoriano, Cristina
dc.contributor.authorMichalski, Dominik
dc.contributor.authorZamani, Zohreh
dc.contributor.authorBlacquiere, Dylan
dc.contributor.authorJohansson, Elias
dc.contributor.authorCuadrado-Godia, Elisa
dc.contributor.authorVuillier, Fabrice
dc.contributor.authorBode, Felix J.
dc.contributor.authorCaparros, François
dc.contributor.authorMaier, Frank
dc.contributor.authorTsivgoulis, Georgios
dc.contributor.authorKatzberg, Hans D.
dc.contributor.authorDuan, Jiangang
dc.contributor.authorBurrow, Jim
dc.contributor.authorPelz, Johann
dc.contributor.authorMbroh, Joshua
dc.contributor.authorOen, Joyce
dc.contributor.authorSchouten, Judith
dc.contributor.authorZimmermann, Julian
dc.contributor.authorNg, Karl
dc.contributor.authorGarambois, Katia
dc.contributor.authorPetruzzellis, Marco
dc.contributor.authorCarvalho Dias, Mariana
dc.contributor.authorGhiasian, Masoud
dc.contributor.authorRomoli, Michele
dc.contributor.authorMiranda, Miguel
dc.contributor.authorWronski, Miriam
dc.contributor.authorSkjelland, Mona
dc.contributor.authorAlmasi-Dooghaee, Mostafa
dc.contributor.authorCuisenier, Pauline
dc.contributor.authorMurphy, Seán
dc.contributor.authorTimsit, Serge
dc.contributor.authorCoutts, Shelagh B.
dc.contributor.authorSchönenberger, Silvia
dc.contributor.authorNagel, Simon
dc.contributor.authorHiltunen, Sini
dc.contributor.authorChatterton, Sophie
dc.contributor.authorCox, Thomas
dc.contributor.authorBartsch, Thorsten
dc.contributor.authorShaygannejad, Vahid
dc.contributor.authorMirzaasgari, Zahra
dc.contributor.authorMiddeldorp, Saskia
dc.contributor.authorLevi, Marcel M.
dc.contributor.authorKremer Hovinga, Johanna A.
dc.contributor.authorJood, Katarina
dc.contributor.authorTatlisumak, Turgut
dc.contributor.authorPutaala, Jukka
dc.contributor.authorHeldner, Mirjam R.
dc.contributor.authorArnold, Marcel
dc.contributor.authorde Sousa, Diana Aguiar
dc.contributor.authorFerro, José
dc.contributor.authorCoutinho, Jonathan M.
dc.date.accessioned2022-09-15T15:28:05Z
dc.date.available2022-09-15T15:28:05Z
dc.date.issued2022
dc.description© 2022 American Heart Association, Inc.pt_PT
dc.description.abstractBackground: Cerebral venous thrombosis (CVT) due to vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe condition, with high in-hospital mortality rates. Here, we report clinical outcomes of patients with CVT-VITT after SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) vaccination who survived initial hospitalization. Methods: We used data from an international registry of patients who developed CVT within 28 days of SARS-CoV-2 vaccination, collected until February 10, 2022. VITT diagnosis was classified based on the Pavord criteria. Outcomes were mortality, functional independence (modified Rankin Scale score 0–2), VITT relapse, new thrombosis, and bleeding events (all after discharge from initial hospitalization). Results: Of 107 CVT-VITT cases, 43 (40%) died during initial hospitalization. Of the remaining 64 patients, follow-up data were available for 60 (94%) patients (37 definite VITT, 9 probable VITT, and 14 possible VITT). Median age was 40 years and 45/60 (75%) patients were women. Median follow-up time was 150 days (interquartile range, 94–194). Two patients died during follow-up (3% [95% CI, 1%–11%). Functional independence was achieved by 53/60 (88% [95% CI, 78%–94%]) patients. No new venous or arterial thrombotic events were reported. One patient developed a major bleeding during follow-up (fatal intracerebral bleed). Conclusions: In contrast to the high mortality of CVT-VITT in the acute phase, mortality among patients who survived the initial hospitalization was low, new thrombotic events did not occur, and bleeding events were rare. Approximately 9 out of 10 CVT-VITT patients who survived the acute phase were functionally independent at follow-up.pt_PT
dc.description.sponsorshipThis study was funded by the Netherlands Organisation for Health Research and Development (ZonMw, grant number 10430072110005), the Dr. C.J. Vaillant Foundation, and Hospital District of Helsinki and Uusimaa (grant TYH2022223).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationStroke. 2022;53:00–00pt_PT
dc.identifier.doi10.1161/STROKEAHA.122.039575pt_PT
dc.identifier.eissn1524-4628
dc.identifier.issn0039-2499
dc.identifier.urihttp://hdl.handle.net/10451/54475
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Heart Associationpt_PT
dc.relation.publisherversionhttps://www.ahajournals.org/journal/strpt_PT
dc.subjectHospitalizationpt_PT
dc.subjectIntracranial thrombosispt_PT
dc.subjectMortalitypt_PT
dc.subjectThrombocytopeniapt_PT
dc.subjectVaccinationpt_PT
dc.subjectVenous thrombosispt_PT
dc.titleOutcomes of cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia after the acute phasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleStrokept_PT
person.familyNameCarvalho Dias
person.familyNameAguiar de Sousa
person.familyNameMorão Cabral Ferro
person.givenNameMariana
person.givenNameDiana
person.givenNameJosé Manuel
person.identifier574112
person.identifier.ciencia-id571C-121A-5CCB
person.identifier.ciencia-id6F16-7E25-7AAF
person.identifier.orcid0000-0002-6603-1796
person.identifier.orcid0000-0002-6702-7924
person.identifier.orcid0000-0002-2343-9097
person.identifier.ridJ-4105-2013
person.identifier.scopus-author-id55781226000
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication95e4f8e1-30e3-41b9-b387-5f234ee4a333
relation.isAuthorOfPublication1d984575-dd95-4ca1-9092-bf6f9914ba63
relation.isAuthorOfPublication9a568ce6-d218-44fc-982c-0ffe7bffc197
relation.isAuthorOfPublication.latestForDiscovery95e4f8e1-30e3-41b9-b387-5f234ee4a333

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