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Influence of the TAS2R38 gene single nucleotide polymorphisms in metabolism and anthropometry in thyroid dysfunction

2023Artigo científico Acesso aberto
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dc.contributor.authorMendes Costa, Marta
dc.contributor.authorSilva, Alda Pereira da
dc.contributor.authorSantos, Ana Carolina
dc.contributor.authorFerreira, Joana
dc.contributor.authorMascarenhas, Mário Rui
dc.contributor.authorBicho, Manuel
dc.contributor.authorBarbosa, Ana
dc.date.accessioned2023-11-14T15:29:58Z
dc.date.available2023-11-14T15:29:58Z
dc.date.issued2023
dc.description© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractThe gene TAS2R38 single nucleotide polymorphisms (SNPs-P49A, A262V and V296I) can condition bitter tasting by PAV (proline–alanine–valine) and non-bitter-tasting by AVI (alanine–valine–isoleucine) homozygosity. We evaluated this polymorphisms association with thyroid function, metabolism and anthropometry parameters determined by: Endpoint analysis (SNPs); DXA (fat mass-%, total fat mass—kg, lean mass—kg); Standard methods (lipid metabolism parameters, HbA1c-%, glycemia—mg/dL, insulinemia—µIU/mL, HOMA-IR, uricemia—mg/dL, calcemia—mg/dL and BMI—kg/m2); ELISA (leptinemia—ng/mL); Spectrophotometry (Angiotensin Converting Enzyme activity—UI/L). Statistics: SPSS program; OR [IC95%]; p < 0.05. Sample: 114 hypothyroid, 49 hyperthyroid, and 179 controls. An association between A262V-valine–valine and hypothyroidism/hyperthyroidism was verified (OR = 2.841; IC95% [1.726–4.676]), p < 0.001/OR = 8.915; IC95% [4.286–18.543]), p < 0.001). Protector effect from thyroid dysfunction: A262V-alanine–valine (OR = 0.467; IC95% [0.289–0.757], p = 0.002/OR = 0.132; IC95% [0.056–0.309], p < 0.001) and PAV (OR = 0.456; IC95% [0.282–0.737], p = 0.001/OR = 0.101; IC95% [0.041–0.250], p < 0.001). Higher parameter values associated with genotypes were: fat-mass-% (V296I-valine–isoleucine), lean-mass (P49A-proline–proline; PVI), leptin (AVI), HbA1c (A262V-alanine–valine) and lower values in lean-Mass (AVI; PVV), leptin (A262V-alanine–alanine), HbA1c (PVV), uricemia (V296I-valine–isoleucine), glycemia (A262V-alanine–alanine; AAV) and plasma triglycerides (PVV). In conclusion, TAS2R38 influences thyroid function, body composition and metabolism. Bitter taste perception (PAV) and the genotype A262V-alanine–valine can protect from thyroid dysfunction. AVV, PVV and genotype A262V-valine–valine may confer higher predisposition for thyroid dysfunction, particularly PVV for hyperthyroidism.pt_PT
dc.description.sponsorshipThe writing of the manuscript was also supported by funds from the Foundation for Science and Technology to ISAMB (ref. UIDB/04295/2020 and UIDP/04295/2020).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNutrients. 2023 May 6;15(9):2214pt_PT
dc.identifier.doi10.3390/nu15092214pt_PT
dc.identifier.eissn2072-6643
dc.identifier.urihttp://hdl.handle.net/10451/60545
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEnvironmental Health Institute
dc.relationEnvironmental Health Institute
dc.relation.publisherversionhttps://www.mdpi.com/journal/nutrientspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTAS2R38pt_PT
dc.subjectBitter tastept_PT
dc.subjectHyperthyroidismpt_PT
dc.subjectHypothyroidismpt_PT
dc.subjectPolymorphisms P49A/A262V/V296Ipt_PT
dc.titleInfluence of the TAS2R38 gene single nucleotide polymorphisms in metabolism and anthropometry in thyroid dysfunctionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEnvironmental Health Institute
oaire.awardTitleEnvironmental Health Institute
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04295%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04295%2F2020/PT
oaire.citation.issue9pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume15pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMendes Costa
person.familyNamePereira da Silva Oliveira
person.familyNameCasinhas dos Santos
person.familyNameFerreira
person.familyNameMascarenhas
person.familyNameBicho
person.givenNameMarta
person.givenNameAlda
person.givenNameAna Carolina
person.givenNameJoana
person.givenNameMário Rui
person.givenNameManuel
person.identifier1234753
person.identifier.ciencia-id0F18-DD24-60C9
person.identifier.ciencia-id6116-BD41-531E
person.identifier.ciencia-id9512-8D22-1B28
person.identifier.orcid0009-0005-7722-0268
person.identifier.orcid0000-0003-4496-2714
person.identifier.orcid0000-0003-3688-4648
person.identifier.orcid0000-0002-3527-3274
person.identifier.orcid0000-0002-5181-4376
person.identifier.orcid0000-0002-5773-5687
person.identifier.scopus-author-id13407552800
person.identifier.scopus-author-id7004153755
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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