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Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties

2020-02-14Artigo científico Acesso aberto
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dc.contributor.authorCouto, Joana
dc.contributor.authorFigueirinha, Artur
dc.contributor.authorBatista, Maria Teresa
dc.contributor.authorParanhos, António
dc.contributor.authorNunes, Carla
dc.contributor.authorGonçalves, Lídia
dc.contributor.authorMarto, Joana
dc.contributor.authorFitas, Manuel
dc.contributor.authorPinto, Pedro
dc.contributor.authorRibeiro, Helena Margarida
dc.contributor.authorPina, Maria Eugénia
dc.date.accessioned2024-01-22T17:00:28Z
dc.date.available2024-01-22T17:00:28Z
dc.date.issued2020-02-14
dc.date.updated2023-02-27T18:31:05Z
dc.description© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractFragaria vesca L. (F. vesca), popularly known as wild strawberry, is a plant from the Rosaceae family, found in temperate and subtropical areas of the northern hemisphere. F. vesca leaves have been shown to have antiseptic, emollient, and dermatological protection properties, due to the presence of bioactive compounds, such as flavonoids, phenolic acids, ellagitannins, and proanthocyanidins. In this study, a F. vesca extract was obtained by an optimized extraction process, and was characterized by HPLC, ROS scavenging activity, cytotoxicity assays in HaCaT cells, and tyrosinase inhibitory activity determination. The most active extract was then incorporated in a hydrogel with hydroxyethylcellulose at 2% (w/w), which was characterized at the physicochemical, stability, cytotoxicity, and ROS scavenging activity levels to evaluate its quality, safety, and efficacy. In vivo studies, human repeat insult patch testing, and an assay to determine their antioxidant efficacy, were also performed. The results showed that the Fragaria vesca extracts had antioxidant activity and that the F. vesca extract-based hydrogel exhibited cutaneous compatibility, acceptability and antioxidant efficacy, being stable, and suitable for topical application.pt_PT
dc.description.sponsorshipThis work was supported by UID/QUI/50006/2019 with funding from FCT/MCTES through national funds, and by Programa de Cooperación Interreg V-A España—Portugal (POCTEP) 2014–2020 (project 0377_IBERPHENOL_6_E). This research was also funded by Fundação para a Ciência e a Tecnologia, Portugal (UID/DTP/04138/2019 to iMedUlisboa) and by PhD Trials.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCouto J, Figueirinha A, Batista MT, Paranhos A, Nunes C, Gonçalves LM, et al. Fragaria vesca l. Extract: a promising cosmetic ingredient with antioxidant properties. Antioxidants [Internet]. 14 de fevereiro de 2020;9(2):154. Disponível em: https://www.mdpi.com/2076-3921/9/2/154pt_PT
dc.identifier.doi10.3390/antiox9020154pt_PT
dc.identifier.eid2-s2.0-85079683806
dc.identifier.slugcv-prod-1178398
dc.identifier.urihttp://hdl.handle.net/10451/62012
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationResearch Institute for Medicines
dc.relation.publisherversionhttps://www.mdpi.com/2076-3921/9/2/154pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFragaria vesca L.pt_PT
dc.subjectantioxidant propertiespt_PT
dc.subjecthydrogelpt_PT
dc.subjecttopical applicationpt_PT
dc.subjectcutaneous compatibilitypt_PT
dc.titleFragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Propertiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleResearch Institute for Medicines
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F50006%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FDTP%2F04138%2F2019/PT
oaire.citation.endPage154pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage154pt_PT
oaire.citation.titleAntioxidantspt_PT
oaire.citation.volume9pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBordalo Machado Figueirinha
person.familyNameBatista
person.familyNamedos Santos Nunes
person.familyNameDiogo Gonçalves
person.familyNameMarques Marto
person.familyNameCapêlo Contreiras Pinto
person.familyNameRibeiro
person.familyNamePina
person.givenNameArtur Manuel
person.givenNameMaria Teresa
person.givenNameCarla Maria
person.givenNameLídia Maria
person.givenNameJoana
person.givenNamePedro Filipe
person.givenNameHelena
person.givenNameEugénia
person.identifier1570599
person.identifier.ciencia-id421A-DC13-3475
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person.identifier.ciencia-id7211-22BA-86AD
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person.identifier.ciencia-id8D15-FEBC-C15C
person.identifier.ciencia-id161F-B79B-D660
person.identifier.ciencia-id1617-96FC-4CB9
person.identifier.orcid0000-0003-3064-5718
person.identifier.orcid0000-0003-4183-6202
person.identifier.orcid0000-0002-7452-1592
person.identifier.orcid0000-0002-6799-2740
person.identifier.orcid0000-0001-5523-5622
person.identifier.orcid0000-0002-5723-0750
person.identifier.orcid0000-0002-2429-7991
person.identifier.orcid0000-0003-0189-1370
person.identifier.ridE-2944-2015
person.identifier.scopus-author-id7005481959
person.identifier.scopus-author-id35896704400
person.identifier.scopus-author-id35572153900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid7211-22BA-86AD | Lídia Maria Diogo Gonçalves
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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