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Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells

2020Journal article Restricted access
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dc.contributor.authorFerreira, Cristina
dc.contributor.authorBarros, Leandro
dc.contributor.authorBaptista, Marta
dc.contributor.authorBlankenhaus, Birte
dc.contributor.authorBarros, André
dc.contributor.authorFigueiredo-Campos, Patricia
dc.contributor.authorKonjar, Spela
dc.contributor.authorLainé, Alexandra
dc.contributor.authorKamenjarin, Nadine
dc.contributor.authorStojanovic, Ana
dc.contributor.authorCerwenka, Adelheid
dc.contributor.authorProbst, Hans C
dc.contributor.authorMarie, Julien C
dc.contributor.authorVeldhoen, Marc
dc.date.accessioned2021-07-23T11:27:45Z
dc.date.available2021-07-23T11:27:45Z
dc.date.issued2020
dc.description© The Author(s), under exclusive licence to Springer Nature America, Inc. 2020pt_PT
dc.description.abstractTissue-resident memory T (TRM) cells, functionally distinct from circulating memory T cells, have a critical role in protective immunity in tissues, are more efficacious when elicited after vaccination and yield more effective antitumor immunity, yet the signals that direct development of TRM cells are incompletely understood. Here we show that type 1 regulatory T (Treg) cells, which express the transcription factor T-bet, promote the generation of CD8+ TRM cells. The absence of T-bet-expressing type 1 Treg cells reduces the presence of TRM cells in multiple tissues and increases pathogen burden upon infectious challenge. Using infection models, we show that type 1 Treg cells are specifically recruited to local inflammatory sites via the chemokine receptor CXCR3. Close proximity with effector CD8+ T cells and Treg cell expression of integrin-β8 endows the bioavailability of transforming growth factor-β in the microenvironment, thereby promoting the generation of CD8+ TRM cells.pt_PT
dc.description.sponsorshipThe project leading to these results has received funding from the European Union H2020 ERA project (no. 667824, EXCELLtoINNOV), Fundo iMM-Laço and ‘la caixa’ Foundation (ID 100010434) under agreement LCF/PR/HR19/52160005 for work in the Veldhoen laboratory, with additional funding from the Fundação para a Ciência e a Tecnologia to P.F.-C. (SFRH/BD/131605/2017), to L.B. (PD/BD/138847/2018) and to A.B. (SFRH/BD/138900/2018). In addition, the work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) SFB1366 (project no. 394046768-SFB 1366; C02) and by SPP 1937 (CE 140/2-1) to A.C and SFB1292 (TP13) and TR156 (TPB02) to H.C.P. A.L. was supported by Ligue Nationale Contre le Cancer. Other grants supporting this study: Foncer Contre le Cancer (JCM) and EL-2016 LNCC Labelisation Ligue Nationale Contre Cancer.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNat Immunol. 2020 Jul;21(7):766-776pt_PT
dc.identifier.doi10.1038/s41590-020-0674-9pt_PT
dc.identifier.eissn1529-2916
dc.identifier.issn1529-2908
dc.identifier.urihttp://hdl.handle.net/10451/49080
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationLCF/PR/HR19/52160005pt_PT
dc.relationLeverage research EXCELLence and INNOVation potential of Instituto de Medicina Molecular (IMM) through translational biomedical research in immunity and infection.
dc.relation“How to activate non-conventional Epithelial T cells”
dc.relationDe novo generation of tissue resident memory T cells
dc.relation.publisherversionhttps://www.nature.com/ni/pt_PT
dc.titleType 1 Treg cells promote the generation of CD8+ tissue-resident memory T cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLeverage research EXCELLence and INNOVation potential of Instituto de Medicina Molecular (IMM) through translational biomedical research in immunity and infection.
oaire.awardTitle“How to activate non-conventional Epithelial T cells”
oaire.awardTitleDe novo generation of tissue resident memory T cells
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/667824/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F131605%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F138847%2F2018/PT
oaire.citation.endPage776pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage766pt_PT
oaire.citation.titleNature Immunologypt_PT
oaire.citation.volume21pt_PT
oaire.fundingStreamH2020
oaire.fundingStreamOE
person.familyNameFerreira
person.familyNameBarros
person.familyNameBlankenhaus
person.familyNameBarros
person.familyNameFigueiredo-Campos
person.familyNameKonjar
person.familyNameVeldhoen
person.givenNameCristina
person.givenNameLeandro
person.givenNameBirte
person.givenNameAndré
person.givenNamePatricia
person.givenNameSpela
person.givenNameMarc
person.identifierhttps://scholar.google.pt/citations?hl=en&user=7vG1jLIAAAAJ
person.identifier.ciencia-id7B1A-BC32-66FB
person.identifier.ciencia-idFD19-D7A4-E29D
person.identifier.ciencia-id2E1E-1B76-0C5D
person.identifier.ciencia-idEC16-8D36-C5F9
person.identifier.ciencia-id6413-A3A0-C7AD
person.identifier.orcid0000-0001-6746-932X
person.identifier.orcid0000-0002-7339-9994
person.identifier.orcid0000-0003-0987-5228
person.identifier.orcid0000-0002-6139-5013
person.identifier.orcid0000-0002-9808-6230
person.identifier.orcid0000-0002-8969-0233
person.identifier.orcid0000-0002-1478-9562
person.identifier.scopus-author-id57191092333
person.identifier.scopus-author-id8323789000
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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