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Which outcomes should be used in future bronchiolitis trials? Developing a bronchiolitis core outcome set using a systematic review, Delphi survey and a consensus workshop

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dc.contributor.authorRosala-Hallas, A.
dc.contributor.authorJones, Ashley P.
dc.contributor.authorWilliamson, Paula R.
dc.contributor.authorBedson, Emma
dc.contributor.authorCompton, Vanessa
dc.contributor.authorFernandes, Ricardo M.
dc.contributor.authorLacy, David
dc.contributor.authorLyttle, Mark David
dc.contributor.authorPeak, Matthew
dc.contributor.authorThorburn, Kentigern
dc.contributor.authorWoolfall, Kerry
dc.contributor.authorVan Miert, Clare
dc.contributor.authorMcNamara, Paul S.
dc.date.accessioned2022-03-24T16:35:40Z
dc.date.available2022-03-24T16:35:40Z
dc.date.issued2022
dc.description© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.pt_PT
dc.description.abstractObjectives: The objective of this study was to develop a core outcome set (COS) for use in future clinical trials in bronchiolitis. We wanted to find out which outcomes are important to healthcare professionals (HCPs) and to parents and which outcomes should be prioritised for use in future clinical trials. Design and setting: The study used a systematic review, workshops and interviews, a Delphi survey and a final consensus workshop. Results: Thirteen parents and 45 HCPs took part in 5 workshops; 15 other parents were also separately interviewed. Fifty-six items were identified from the systematic review, workshops and interviews. Rounds one and two of the Delphi survey involved 299 and 194 participants, respectively. Sixteen outcomes met the criteria for inclusion within the COS. The consensus meeting was attended by 10 participants, with representation from all three stakeholder groups. Nine outcomes were added, totalling 25 outcomes to be included in the COS. Conclusion: We have developed the first parent and HCP consensus on a COS for bronchiolitis in a hospital setting. The use of this COS will ensure outcomes in future bronchiolitis trials are important and relevant, and will enable the trial results to be compared and combined. Trial registration number: ISRCTN75766048.pt_PT
dc.description.sponsorshipThis study formed part of a larger research project (Non-Invasive Ventilation for the Management of Children with Bronchiolitis: a feasibility study (NOVEMBR)) which was funded by the National Institute for Health Research (NIHR), Research for Patient Benefit (RfPB) Programme (Grant Reference Number: PB-PG-1014–35081).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMJ Open. 2022 Mar 9;12(3):e052943pt_PT
dc.identifier.doi10.1136/bmjopen-2021-052943pt_PT
dc.identifier.eissn2044-6055
dc.identifier.urihttp://hdl.handle.net/10451/51963
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.relation.publisherversionhttps://bmjopen.bmj.com/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectBronchiolitispt_PT
dc.subjectCore outcome setspt_PT
dc.subjectPaediatricspt_PT
dc.titleWhich outcomes should be used in future bronchiolitis trials? Developing a bronchiolitis core outcome set using a systematic review, Delphi survey and a consensus workshoppt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleBMJ Openpt_PT
person.familyNameFernandes
person.givenNameRicardo
person.identifier309018
person.identifier.orcid0000-0002-7253-6475
person.identifier.ridC-7501-2015
person.identifier.scopus-author-id24436565500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication862be38f-2247-424c-b26c-d3bdda4474be
relation.isAuthorOfPublication.latestForDiscovery862be38f-2247-424c-b26c-d3bdda4474be

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