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Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites

2019Journal article Restricted access
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dc.contributor.authorAguiar, LuĂ­sa
dc.contributor.authorMachado, Marta
dc.contributor.authorSanches-Vaz, Margarida
dc.contributor.authorPrudĂȘncio, Miguel
dc.contributor.authorVale, Nuno
dc.contributor.authorGomes, Paula
dc.date.accessioned2022-08-24T11:33:42Z
dc.date.available2022-08-24T11:33:42Z
dc.date.issued2019
dc.descriptionThis journal is © The Royal Society of Chemistry 2018pt_PT
dc.description.abstractNovel primaquine-cell penetrating peptide conjugates were synthesised and tested in vitro against liver stage Plasmodium berghei parasites. Generally, the conjugates were more active than the parent peptides and, in some cases, than the parent drug. These are unprecedented findings that may open a new route towards antimalarial drug rescuing.pt_PT
dc.description.sponsorshipThe authors are indebted to Fundação para a CiĂȘncia e Tecnologia (FCT, Portugal) for funding LAQV-REQUIMTE re- search unit through project UID/QUI/50006/2013. NV thanks FCT and FEDER (European Union) for funding project IF/00092/2014/CP1255/CT0004 and IF position. LA thanks FCT and the Medicinal Biochemistry and Biochemistry International Doctoral Programme (M2B-PhD) for PhD grant PD/BD/106035/2015.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMedchemcomm. 2018 Nov 16;10(2):221-226pt_PT
dc.identifier.doi10.1039/C8MD00447Apt_PT
dc.identifier.issn2040-2511
dc.identifier.urihttp://hdl.handle.net/10451/54178
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationNew advance in biomedicine: peptide-mediated target drug delivery
dc.relationTaxi - targeting antimalarial ex- star dugs for intracellular delivery
dc.relation.publisherversionhttps://pubs.rsc.org/en/journals/journalissues/md#!recentarticles&advpt_PT
dc.titleCoupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasitespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleNew advance in biomedicine: peptide-mediated target drug delivery
oaire.awardTitleTaxi - targeting antimalarial ex- star dugs for intracellular delivery
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F50006%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00092%2F2014%2FCP1255%2FCT0004/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F106035%2F2015/PT
oaire.citation.endPage226pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage221pt_PT
oaire.citation.titleMedChemCommpt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamInvestigador FCT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a CiĂȘncia e a Tecnologia
project.funder.nameFundação para a CiĂȘncia e a Tecnologia
project.funder.nameFundação para a CiĂȘncia e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isProjectOfPublication5a0e0f53-144d-46b5-b57c-411a205f553e
relation.isProjectOfPublication57b85e5c-bcbe-44e5-b2f7-b58927a59df7
relation.isProjectOfPublication.latestForDiscovery5a0e0f53-144d-46b5-b57c-411a205f553e

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