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The European Vasculitis Society 2016 Meeting report

2017Artigo científico Acesso aberto
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dc.contributor.authorBajema, Ingeborg M.
dc.contributor.authorBruijn, Jan A.
dc.contributor.authorCasian, Alina
dc.contributor.authorCid, Maria C.
dc.contributor.authorCsernok, Elena
dc.contributor.authorvan Daalen, Emma
dc.contributor.authorHarper, Lorraine
dc.contributor.authorHauser, Thomas
dc.contributor.authorLittle, Mark A.
dc.contributor.authorLuqmani, Raashid A.
dc.contributor.authorMahr, Alfred
dc.contributor.authorPonte, Cristina
dc.contributor.authorSalama, Alan
dc.contributor.authorSegelmark, Mårten
dc.contributor.authorSuzuki, Kazuo
dc.contributor.authorSznajd, Jan
dc.contributor.authorTeng, Y. K. Onno
dc.contributor.authorVaglio, Augusto
dc.contributor.authorWestman, Kerstin
dc.contributor.authorJayne, David
dc.date.accessioned2022-02-23T16:16:36Z
dc.date.available2022-02-23T16:16:36Z
dc.date.issued2017
dc.description© 2017 International Society of Nephrology. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).pt_PT
dc.description.abstractThe 2016 European Vasculitis Society (EUVAS) meeting, held in Leiden, the Netherlands, was centered around phenotypic subtyping in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). There were parallel meetings of the EUVAS petals, which here report on disease assessment; database; and long-term follow-up, registries, genetics, histology, biomarker studies, and clinical trials. Studies currently conducted will improve our ability to discriminate between different forms of vasculitis. In a project that involves the 10-year follow-up of AAV patients, we are working on retrieving data on patient and renal survival, relapse rate, the cumulative incidence of malignancies, and comorbidities. Across Europe, several vasculitis registries were developed covering over 10,000 registered patients. In the near future, these registries will facilitate clinical research in AAV on a scale hitherto unknown. Current studies on the genetic background of AAV will explore the potential prognostic significance of genetic markers and further refine genetic associations with distinct disease subsets. The histopathological classification of ANCA-associated glomerulonephritis is currently evaluated in light of data coming out of a large international validation study. In our continuous search for biomarkers to predict clinical outcome, promising new markers are important subjects of current research. Over the last 2 decades, a host of clinical trials have provided evidence for refinement of therapeutic regimens. We give an overview of clinical trials currently under development, and consider refractory vasculitis in detail. The goal of EUVAS is to stimulate ongoing research in clinical, serological, and histological management and techniques for patients with systemic vasculitis, with an outlook on the applicability for clinical trials.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationKidney International Reports (2017) 2, 1018–1031pt_PT
dc.identifier.doi10.1016/j.ekir.2017.09.008pt_PT
dc.identifier.issn2468-0249
dc.identifier.urihttp://hdl.handle.net/10451/51483
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/kidney-international-reportspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectANCApt_PT
dc.subjectRenal outcomept_PT
dc.subjectTherapypt_PT
dc.subjectVasculitispt_PT
dc.titleThe European Vasculitis Society 2016 Meeting reportpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1031pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1018pt_PT
oaire.citation.titleKidney International Reportspt_PT
oaire.citation.volume2pt_PT
person.familyNamePonte
person.givenNameCristina
person.identifier.ciencia-id3713-901B-4493
person.identifier.orcid0000-0002-3989-1192
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication22483f4f-a4d7-48f5-9fae-cc5ae926528a
relation.isAuthorOfPublication.latestForDiscovery22483f4f-a4d7-48f5-9fae-cc5ae926528a

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