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Comparação da variação dos valores séricos de proteína C-reactiva (PCR) entre cirurgia com laser de dióxido de carbono (CO2) e cirurgia com lâmina de bisturi, nos períodos pré- e pós-cirúrgicos em doentes da espécie Canis familiaris
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Resumo(s)
No cão, a Proteína C-Reactiva (PCR) representa uma proteína de fase aguda (PFA)
assumindo a função de marcador inflamatório, e apresentando maior sensibilidade,
estabilidade e uma resposta mais rápida relativamente a outros marcadores inflamatórios,
como por exemplo, a contagem de leucócitos (WBC). Comparativamente aos métodos
convencionais de incisão cirúrgica, o Laser de Dióxido de Carbono (CO2) está associado a
múltiplas vantagens como a menor hemorragia, edema e dor para o doente. O estudo foi
realizado numa amostra de 50 cadelas (n=50), dividida aleatoriamente em 2 grupos de 25
animais cada um, e sujeitas a cirurgia do tipo Ovariohisterectomia electiva (OVH). Teve
como objectivos: 1) comparar os níveis de inflamação pós-cirúrgica causados pela técnica
de incisão com lâmina de bisturi (GB) ou laser de CO2 (GL) através da quantificação da
variação da PCR; 2) avaliar a influência de vários parâmetros na variação da PCR. A cada
doente foi realizada uma colheita de um volume de 1 ml de sangue periférico em 2 tempos
diferentes: T0 (pré-cirúrgico e logo após a cateterização) e T1 (4 horas após terminar a
cirurgia), para quantificar a concentração da PCR. De acordo com os resultados obtidos foi
possível verificar a existência de uma diferença estatisticamente significativa na variação
da concentração de PCR entre T0 e T1 em GB e GL, com valores mais baixos para as
doentes de GL (p <0,01). Considerando que não existiram diferenças estatisticamente
significativas para os restantes parâmetros estudados entre GB e GL, é possível concluir
que o uso do laser de CO2 na cirurgia está associado a um melhor controlo do fenómeno
de inflamação tecidular num cenário cirúrgico, comparativamente ao uso da lâmina de
bisturi. O resultado da sua utilização traduzir-se-á numa recuperação pós-operatória mais
rápida e com menor dor para o doente.
ABSTRACT - COMPARATIVE STUDY ON THE VARIATION OF C-REACTIVE PROTEIN (CRP) SERUM CONCENTRATIONS BETWEEN SURGERY WITH CARBON DIOXIDE (CO2) LASER AND SCALPEL BLADE, IN THE PRE- AND POST-SURGICAL TIMEPOINTS IN CANIS FAMILIARIS PATIENTS - In the dog, C-Reactive Protein (CRP) is an acute phase protein (APP) functioning as an inflammatory marker, having a higher sensitivity, stability, and a faster response in comparison with other inflammatory markers, such as white blood cell (WBC) counts. Comparatively with conventional surgery incision methods, the Carbon Dioxide (CO2) Laser is associated with multiple advantages like decreased haemorrhage, oedema and pain for the patient. This study was performed on a sample of 50 female dogs (n=50), randomly split by two groups of 25 animals each, and subjected to elective Ovariohysterectomy (OVH) surgery. The study had the following objectives: 1) compare the levels of postsurgical inflammation caused by the incision technique with scalpel blade (GB) or CO2 laser (GL) through the quantification of CRP; 2) evaluate the influence of several parameters on the variation of CRP concentrations. From each patient, a sample of 1 ml of peripheral blood was collected at two time-points: T0 (pre-surgical and immediately after catheterization) and T1 (4 hours after the end of surgery), to quantify CRP concentration. According to the results obtained there was a statistically significant difference in the variation of CRP concentration between T0 and T1 in GB and GL, with lower values for patients in GL (p < 0,01). Considering that there were no statistically significant differences for the remaining parameters studied between GB and GL, it is possible to conclude that the use of the CO2 laser in surgery is associated with a better control of the tissue inflammation phenomenon in surgical scenario, comparatively to the use of scalpel blade. Its use will result in a faster post-operative recovery with less pain for the patient.
ABSTRACT - COMPARATIVE STUDY ON THE VARIATION OF C-REACTIVE PROTEIN (CRP) SERUM CONCENTRATIONS BETWEEN SURGERY WITH CARBON DIOXIDE (CO2) LASER AND SCALPEL BLADE, IN THE PRE- AND POST-SURGICAL TIMEPOINTS IN CANIS FAMILIARIS PATIENTS - In the dog, C-Reactive Protein (CRP) is an acute phase protein (APP) functioning as an inflammatory marker, having a higher sensitivity, stability, and a faster response in comparison with other inflammatory markers, such as white blood cell (WBC) counts. Comparatively with conventional surgery incision methods, the Carbon Dioxide (CO2) Laser is associated with multiple advantages like decreased haemorrhage, oedema and pain for the patient. This study was performed on a sample of 50 female dogs (n=50), randomly split by two groups of 25 animals each, and subjected to elective Ovariohysterectomy (OVH) surgery. The study had the following objectives: 1) compare the levels of postsurgical inflammation caused by the incision technique with scalpel blade (GB) or CO2 laser (GL) through the quantification of CRP; 2) evaluate the influence of several parameters on the variation of CRP concentrations. From each patient, a sample of 1 ml of peripheral blood was collected at two time-points: T0 (pre-surgical and immediately after catheterization) and T1 (4 hours after the end of surgery), to quantify CRP concentration. According to the results obtained there was a statistically significant difference in the variation of CRP concentration between T0 and T1 in GB and GL, with lower values for patients in GL (p < 0,01). Considering that there were no statistically significant differences for the remaining parameters studied between GB and GL, it is possible to conclude that the use of the CO2 laser in surgery is associated with a better control of the tissue inflammation phenomenon in surgical scenario, comparatively to the use of scalpel blade. Its use will result in a faster post-operative recovery with less pain for the patient.
Descrição
Dissertação de Mestrado Integrado em Medicina Veterinária
Palavras-chave
Cão Proteína C-Reactiva Laser de Dióxido de Carbono Lâmina de Bisturi Cirurgia Dog C-Reactive Protein Carbon Dioxide Laser Scalpel Blade Surgery
Contexto Educativo
Citação
Silva, L.P. (2018). Comparação da variação dos valores séricos de proteína C-reactiva (PCR) entre cirurgia com laser de dióxido de carbono (CO2) e cirurgia com lâmina de bisturi, nos períodos pré- e pós-cirúrgicos em doentes da espécie Canis familiaris. Dissertação de mestrado. Universidade de Lisboa, Faculdade de Medicina Veterinária, Lisboa.
Editora
Universidade de Lisboa, Faculdade de Medicina Veterinária