Publicação
Uncovering the interactions between deleterious mutations, divergent selection and migration
| datacite.subject.fos | Departamento de Biologia Animal | pt_PT |
| dc.contributor.advisor | Sousa, Vítor Martins Conde e, 1981- | |
| dc.contributor.author | Caneira, Gonçalo Abrantes | |
| dc.date.accessioned | 2022-07-11T12:18:58Z | |
| dc.date.available | 2024-02-17T01:32:01Z | |
| dc.date.issued | 2022 | |
| dc.date.submitted | 2022 | |
| dc.description | Tese de mestrado, Biologia Evolutiva e do Desenvolvimento, Universidade de Lisboa, Faculdade de Ciências, 2022 | pt_PT |
| dc.description.abstract | Background selection (BGS) and associative overdominance (AOD) are processes describing the effect of removal of deleterious mutations on linked neutral variation. Mathematical modelling and sim ulations predict that, in comparison to neutrality, BGS leads to reduced genetic diversity while AOD leads to an increase, with greater effects in low recombining regions. However, little is known about the impact of migration and hemizygosity (X-chromosomes or haplodiploid sex-determining system). Moreover, studies about divergent selection with migration usually ignore deleterious mutations. The objective of this thesis was to use simulations to predict genomic patterns of diversity and differenti ation resulting from the interaction between deleterious mutations, divergent selection, migration and haplodiploidy. We used forward-in-time simulations under an isolation-with-migration model with two populations, investigating variation in dominance, migration rate, recombination rate, and selective co efficients. To assess the impact of interactions between deleterious mutations and divergent selection, we performed simulations according to the demographic history from two sister species of haplodiploid Neodiprion sawflies to simulate a real-life based model. We found that the pattern of variation of the ratio of within population nucleotide diversity over its neutral expectation (π/πneutral) as a function of deleterious selective coefficient is only slightly influenced by gene flow. However, the ratio of between population differentiation (FST /FSTneutral) becomes closer to 1 as migration rate increases, suggesting a migration threshold above which linked selection has no effect on FST . We found a lower migration threshold for genomic regions under BGS than AOD. For fully and partially recessive deleterious mutations we discovered a transition between AOD and BGS as selective coefficients increased, both with and without migration. Finally, we introduce predictions for the genomic patterns of haplodiploid populations experiencing divergent selection and asymmetric gene flow. | pt_PT |
| dc.identifier.tid | 203198077 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10451/53747 | |
| dc.language.iso | eng | pt_PT |
| dc.subject | Background Selection | pt_PT |
| dc.subject | Associative Overdominance | pt_PT |
| dc.subject | Mutações Deletérias | pt_PT |
| dc.subject | Fluxo Génico | pt_PT |
| dc.subject | Seleção Divergente | pt_PT |
| dc.subject | Teses de mestrado - 2022 | pt_PT |
| dc.title | Uncovering the interactions between deleterious mutations, divergent selection and migration | pt_PT |
| dc.type | master thesis | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | masterThesis | pt_PT |
| thesis.degree.name | Tese de mestrado em Biologia Evolutiva e do Desenvolvimento | pt_PT |