Repository logo
 
Publication

Low frequency of NS5A relevant resistance-associated substitutions to Elbasvir among hepatitis C virus genotype 1a in Spain: A cross-sectional study

2017Journal article Open access
Simple item page
dc.contributor.authorPalladino, Claudia
dc.contributor.authorSánchez-Carrillo, Marta
dc.contributor.authorMaté-Cano, Irene
dc.contributor.authorVázquez-Morón, Sonia
dc.contributor.authorJimenez-Sousa, Maria Ángeles
dc.contributor.authorGutiérrez-Rivas, Mónica
dc.contributor.authorResino, Salvador
dc.contributor.authorBriz, Verónica
dc.date.accessioned2023-08-31T20:27:39Z
dc.date.available2023-08-31T20:27:39Z
dc.date.issued2017
dc.date.updated2023-02-09T15:01:39Z
dc.description.abstractRelevant resistance-associated substitutions (RASs) to elbasvir, the new HCV NS5A inhibitor, may limit its efficacy and lead to virological failure in HCV-GT1a-infected patients. There are few data outside clinical trials evaluating their prevalence and impact of elbasvir/grazoprevir. A multicenter cross-sectional study of 617 HCV-GT1a-infected individuals attended in 84 Spanish hospitals from the 17 Autonomous Communities and two Autonomous cities was performed. HCV population sequencing was used to identify RASs to elbasvir and the mutational pattern and drug sensitivity were confirmed by geno2pheno[HCV]. Viruses bearing RASs to elbasvir were present in 6.2% of HCV-GT1a infected patients. The most common RASs were the Y93C/H/N and Q30E/H/R (2.4% and 2.3%; respectively). Only 3.4% of patients had viruses with RASs that confer reduced susceptibility to elbasvir by geno2pheno[HCV] that identified exclusively the positions Q30H/R (n = 7) and Y93C/H/N (n = 8) as single mutations and Q30H + Y93H (n = 4) and Q30R + Y93H (n = 2) as double mutations considered as RASs to elbasvir. Lower prevalence of RASs to elbasvir in our HCV-GT1a-Spanish cohort was observed than reported previously in clinical trials. This information may be essential to guiding the implementation of elbasvir/grazoprevir in Spain, expected at the beginning of 2017 and the management of GT1a-infected patients.pt_PT
dc.description.sponsorshipThe authors would like to thank all the centers and investigators involved in Spanish Group of Chronic Viral Hepatitis (see Supplemental Data) and patients for their participation and the clinical samples provided. This work was supported by grants from ‘Instituto de Salud Carlos III’ (Ref. PI14CIII/00011 to SR, MPY 1039/14 and PI15CIII/00031 to VB). CP is supported by the Portuguese ‘Fundação para a Ciência e Tecnologia’ (FCT) (grant number SFRH/BPD/77448/2011, part of the EDCTP2 program supported by the European Union). VB is supported by the Miguel Servet program run by the ‘Fondo de Investigación Sanitaria’ (ISCIII) (grant number CP13/00098). MAJS is supported by ‘Instituto de Salud Carlos III’ (grant numbers CD13/00013).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPalladino C, Sánchez-Carrillo M, Mate-Cano I, Vázquez-Morón S, Jimenez-Sousa MÁ, Gutiérrez-Rivas M, et al. Low frequency of NS5A relevant resistance-associated substitutions to Elbasvir among hepatitis C virus genotype 1a in Spain: a cross-sectional study. Sci Rep [Internet]. 6 de junho de 2017;7(1):2892. Disponível em: https://www.nature.com/articles/s41598-017-02968-7pt_PT
dc.identifier.doi10.1038/s41598-017-02968-7pt_PT
dc.identifier.eid2-s2.0-85020415072
dc.identifier.slugcv-prod-1185526
dc.identifier.urihttp://hdl.handle.net/10451/59115
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationEPIDEMIOLOGY, PATHOGENESIS AND DETERMINANTS OF HIV-1 TRANSMISSION AND DISEASE PROGRESSION IN THE ANGOLAN PERINATAL HIV COHORT APEHC
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-017-02968-7pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleLow frequency of NS5A relevant resistance-associated substitutions to Elbasvir among hepatitis C virus genotype 1a in Spain: A cross-sectional studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEPIDEMIOLOGY, PATHOGENESIS AND DETERMINANTS OF HIV-1 TRANSMISSION AND DISEASE PROGRESSION IN THE ANGOLAN PERINATAL HIV COHORT APEHC
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F77448%2F2011/PT
oaire.citation.issue1pt_PT
oaire.citation.startPage2892pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume7pt_PT
oaire.fundingStreamOE
person.familyNamePalladino
person.familyNameMaté
person.familyNameResino
person.familyNameBriz
person.givenNameClaudia
person.givenNameIrene
person.givenNameSalvador
person.givenNameVerónica
person.identifier407901
person.identifier.ciencia-id721D-6851-20D5
person.identifier.orcid0000-0002-8148-0928
person.identifier.orcid0000-0002-9045-9581
person.identifier.orcid0000-0001-8783-0450
person.identifier.orcid0000-0003-2297-5098
person.identifier.ridT-4183-2017
person.identifier.scopus-author-id9332849600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid721D-6851-20D5 | Claudia Palladino
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication96b2385b-89f4-428a-9ab2-6fdb5514541b
relation.isAuthorOfPublication3145c0e5-1ca2-4bdf-b103-9e79218b07cd
relation.isAuthorOfPublicationa428ce68-f89c-4f34-af69-04b11f8717ca
relation.isAuthorOfPublication4612acdd-e150-40d9-9989-a372cfee3499
relation.isAuthorOfPublication.latestForDiscovery3145c0e5-1ca2-4bdf-b103-9e79218b07cd
relation.isProjectOfPublication5c32faa6-8a9f-4fd4-b3a7-fa871a159d96
relation.isProjectOfPublication.latestForDiscovery5c32faa6-8a9f-4fd4-b3a7-fa871a159d96

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2017_Low_frequency_of_NS5A_RAS_to_elbasvir_Palladino.pdf
Size:
1.1 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FF - CiênciaVitae - Faculdade de Farmácia