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Evolutionary stasis of the pseudoautosomal boundary in strepsirrhine primates
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Orientador(es)
Resumo(s)
Sex chromosomes are typically comprised of a non-recombining region and a
recombining pseudoautosomal region. Accurately quantifying the relative size of these regions is
critical for sex-chromosome biology both from a functional and evolutionary perspective. The
evolution of the pseudoautosomal boundary (PAB) is well documented in haplorrhines (apes and
monkeys) but not in strepsirrhines (lemurs and lorises). Here, we studied the PAB of seven species
representing the main strepsirrhine lineages by sequencing a male and a female genome in each
species and using sex differences in coverage to identify the PAB. We found that during primate
evolution, the PAB has remained unchanged in strepsirrhines whereas several recombination
suppression events moved the PAB and shortened the pseudoautosomal region in haplorrhines.
Strepsirrhines are well known to have much lower sexual dimorphism than haplorrhines. We
suggest that mutations with antagonistic effects between males and females have driven
recombination suppression and PAB evolution in haplorrhines
Descrição
Short Report
Palavras-chave
primates
Contexto Educativo
Citação
Shearn et al. eLife 2020;9:e63650.