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Celiac disease and a novel association with a multifocal acquired motor axonopathy (MAMA)

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Celiac disease (CD) is a chronic, multisystem and immunemediated disorder characterized by small-bowel sensitivity to dietary gluten and possibly other environmental factors in genetically predisposed individuals (Alaedini et al., 2002; Rigamonti et al., 2007; Caio et al., 2015). Recent growing evidence strongly suggests a correlation between anti-ganglioside antibodies and neurological syndromes in CD (Alaedini et al., 2002; Chin et al., 2003; Volta et al., 2006). One study showed that at least one type of anti-ganglioside antibody (anti-GM1, GM2, GD1a or GD1b antibodies) was detected in six of twenty-seven CD patients, and all of them had peripheral nerve involvement (Alaedini et al., 2002). Chin et al., (2003) have also found anti-ganglioside antibodies in up to 65% of CD patients with peripheral neuropathy. About 10% of patients with CD have neurological symptoms (Alaedini et al., 2002; Chin et al., 2003; Rigamonti et al., 2007; Caio et al., 2015), but no association to multifocal acquired motor axonopathy (MAMA) has been previously reported.

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© 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

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Clin Neurophysiol. 2017 Sep;128(9):1596-1598

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