Publicação
Skeletal Class III phenotype: link between animal models and human genetics: a scoping review
| dc.contributor.author | Dehesa‐Santos, Alexandra | |
| dc.contributor.author | Faria-Teixeira, Maria Cristina | |
| dc.contributor.author | Iglesias‐Linares, Alejandro | |
| dc.date.accessioned | 2024-01-09T14:46:13Z | |
| dc.date.available | 2024-01-09T14:46:13Z | |
| dc.date.issued | 2023 | |
| dc.description | © 2023 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution published by Wiley Periodicals LLC.This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. | pt_PT |
| dc.description.abstract | This study aimed to identify evidence from animal studies examining genetic variants underlying maxillomandibular discrepancies resulting in a skeletal Class III (SCIII) malocclusion phenotype. Following the Manual for Evidence Synthesis of the JBI and the PRISMA extension for scoping reviews, a participant, concept, context question was formulated and systematic searches were executed in the PubMed, Scopus, WOS, Scielo, Open Gray, and Mednar databases. Of the 779 identified studies, 13 met the selection criteria and were included in the data extraction. The SCIII malocclusion phenotype was described as mandibular prognathism in the Danio rerio, Dicentrarchus labrax, and Equus africanus asinus models; and as maxillary deficiency in the Felis silvestris catus, Canis familiaris, Salmo trutta, and Mus musculus models. The identified genetic variants highlight the significance of BMP and TGF-β signaling. Their regulatory pathways and genetic interactions link them to cellular bone regulation events, particularly ossification regulation of postnatal cranial synchondroses. In conclusion, twenty genetic variants associated with the skeletal SCIII malocclusion phenotype were identified in animal models. Their interactions and regulatory pathways corroborate the role of these variants in bone growth, differentiation events, and ossification regulation of postnatal cranial synchondroses. | pt_PT |
| dc.description.sponsorship | This study was conducted under a pre‐doctoral contract for research personnel in training (CT63/19‐CT64/19). This study was funded by the Complutense University of Madrid and Banco Santander. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | J Exp Zool B Mol Dev Evol. 2024 Jan;342(1):21-44 | pt_PT |
| dc.identifier.doi | 10.1002/jez.b.23230 | pt_PT |
| dc.identifier.eissn | 1552-5015 | |
| dc.identifier.issn | 1552-5007 | |
| dc.identifier.uri | http://hdl.handle.net/10451/61665 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Wiley | pt_PT |
| dc.relation.publisherversion | https://onlinelibrary.wiley.com/journal/15525015 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
| dc.subject | Animal model | pt_PT |
| dc.subject | Genetic variants | pt_PT |
| dc.subject | Mandibular prognathism | pt_PT |
| dc.subject | Maxillary deficiency | pt_PT |
| dc.subject | Skeletal Class III malocclusion phenotype | pt_PT |
| dc.title | Skeletal Class III phenotype: link between animal models and human genetics: a scoping review | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 44 | pt_PT |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 21 | pt_PT |
| oaire.citation.title | Journal of Experimental Zoology Part B: Molecular and Developmental Evolution (JEZ-B) | pt_PT |
| oaire.citation.volume | 342 | pt_PT |
| person.identifier.ciencia-id | 3C10-E25B-FBE4 | |
| person.identifier.orcid | 0000-0002-4707-0773 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | e85df547-cb07-4038-9a08-3a90a2ef4810 | |
| relation.isAuthorOfPublication.latestForDiscovery | e85df547-cb07-4038-9a08-3a90a2ef4810 |