ALTernative functions for human FANCM at telomeres

Domingues Silva, Ana Beatriz; Silva, Bruno; Azzalin, Claus Maria

http://hdl.handle.net/10451/47079

Utilize este identificador para referenciar este registo.

Nome:	Descrição:	Tamanho:	Formato:
ALTernative.pdf		805.64 KB	Adobe PDF	Ver/Abrir

Contacte-nos

Autores

Domingues Silva, Ana Beatriz

Silva, Bruno

Azzalin, Claus Maria

Resumo(s)

The human FANCM ATPase/translocase is involved in various cellular pathways including DNA damage repair, replication fork remodeling and R-loop resolution. Recently, reports from three independent laboratories have disclosed a previously unappreciated role for FANCM in telomerase-negative human cancer cells that maintain their telomeres through the Alternative Lengthening of Telomeres (ALT) pathway. In ALT cells, FANCM limits telomeric replication stress and damage, and, in turn, ALT activity by suppressing accumulation of telomeric R-loops and by regulating the action of the BLM helicase. As a consequence, FANCM inactivation leads to exaggerated ALT activity and ultimately cell death. The studies reviewed here not only unveil a novel function for human FANCM, but also point to this enzyme as a promising target for anti-ALT cancer therapy.

Descrição

Copyright © 2019 Domingues-Silva, Silva and Azzalin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.