Publicação
Essential arterial hypertension patients present higher cell adhesion forces, contributing to fibrinogen-dependent cardiovascular risk
| dc.contributor.author | Guedes, Ana F. | |
| dc.contributor.author | Carvalho, Filomena A. | |
| dc.contributor.author | Moreira, Carlos | |
| dc.contributor.author | Nogueira, José B. | |
| dc.contributor.author | Santos, Nuno C. | |
| dc.date.accessioned | 2018-04-16T13:49:07Z | |
| dc.date.available | 2018-04-16T13:49:07Z | |
| dc.date.issued | 2017 | |
| dc.description | © The Royal Society of Chemistry 2017 | pt_PT |
| dc.description.abstract | The increase of erythrocyte aggregation by high fibrinogen levels may be an indicator of cardiovascular risk. γ' fibrinogen variant has been considered as a possible player in enhancing aggregation. Here, we assessed, at the single-cell level, the influence of fibrinogen on erythrocyte aggregation in essential arterial hypertension. We also aimed at understanding how γ' fibrinogen is altered in this disease. Using atomic force microscopy (AFM), we show that the work and force necessary for erythrocyte-erythrocyte detachment is higher for patients than for healthy donors, with these parameters further increasing in both groups when higher fibrinogen concentrations are present. This can be associated with changes in blood flow, due to transient bridging of two erythrocytes by fibrinogen, representing an important cardiovascular risk factor. γ' fibrinogen can influence the increased risk in essential arterial hypertension, as we demonstrate that its levels are significantly increased in these patients' blood. Nevertheless, this cannot be the only cause for the changes observed in the AFM data. | pt_PT |
| dc.description.sponsorship | This work was supported by Fundação para a Ciência e a Tecnologia – Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal) grants PTDC/QUI-BIQ/119509/2010 and PTDC/BBB-BMD/6307/2014, as well as the fellowship SFRH/BD/84414/2012 to AFG. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Nanoscale, 2017, 9, 14897–14906 | pt_PT |
| dc.identifier.doi | 10.1039/c7nr03891g | pt_PT |
| dc.identifier.issn | 2040-3364 | |
| dc.identifier.uri | http://hdl.handle.net/10451/32819 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Royal Society of Chemistry | pt_PT |
| dc.relation | PTDC/QUI-BIQ/ 119509/2010 | pt_PT |
| dc.relation | Molecular interactions of circulating fibrinogen as a risk factor for cardiovascular and cerebrovascular pathologies | |
| dc.relation | MOLECULAR CHARACTERIZATION OF THE FIBRINOGEN-ERYTHROCYTE INTERACTION AS A CARDIOVASCULAR RISK DETERMINANT | |
| dc.relation.publisherversion | http://pubs.rsc.org/en/Journals/JournalIssues/NR#!recentarticles&adv | pt_PT |
| dc.title | Essential arterial hypertension patients present higher cell adhesion forces, contributing to fibrinogen-dependent cardiovascular risk | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Molecular interactions of circulating fibrinogen as a risk factor for cardiovascular and cerebrovascular pathologies | |
| oaire.awardTitle | MOLECULAR CHARACTERIZATION OF THE FIBRINOGEN-ERYTHROCYTE INTERACTION AS A CARDIOVASCULAR RISK DETERMINANT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBBB-BMD%2F6307%2F2014/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F84414%2F2012/PT | |
| oaire.citation.endPage | 14906 | pt_PT |
| oaire.citation.issue | 39 | pt_PT |
| oaire.citation.startPage | 14897 | pt_PT |
| oaire.citation.title | Nanoscale | pt_PT |
| oaire.citation.volume | 9 | pt_PT |
| oaire.fundingStream | 3599-PPCDT | |
| oaire.fundingStream | OE | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |
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