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Estuarine Aquacultures at the Crossroads of Animal Production and Antibacterial Resistance: A Metagenomic Approach to the Resistome

2022-11-21Journal article Open access
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dc.contributor.authorSilva, Daniel G.
dc.contributor.authorDomingues, Célia P. F.
dc.contributor.authorFigueiredo, João F.
dc.contributor.authorDionisio, Francisco
dc.contributor.authorBotelho, Ana
dc.contributor.authorNogueira, Teresa
dc.date.accessioned2022-12-02T15:19:09Z
dc.date.available2022-12-02T15:19:09Z
dc.date.issued2022-11-21
dc.description.abstractIt is recognized that the spread of antibiotic resistance (AR) genes among aquatic environments, including aquaculture and the human environment, can have detrimental effects on human and animal health and the ecosystem. Thus, when transmitted to the human microbiome or pathogens, resistance genes risk human health by compromising the eventual treatment of infections with antibiotic therapy. This study aimed to define the resistance profile of aquaculture farms and their potential risk for spreading. Twenty-four sediments from oyster and gilthead sea bream aquaculture farms located in three Portuguese river estuaries (17 sediments from Sado, 4 from Aveiro, and 3 from Lima) were studied by comparative metagenomic analysis. The computation of the diversity of genes conferring resistance per antibiotic class revealed a significant increase in aminoglycosides, beta-lactams, disinfectants, quinolones, and tetracyclines counts. In all geographic locations under study, the most diverse AR genes confer resistance to the macrolides, tetracyclines and oxazolidinones classes, all of which are medically important for human and animal therapies, as well as resistance to disinfectants. The diversity of mobile genetic elements correlated with the number of AR genes such as tetracyclines, suggesting that AR could be easily mobilized among bacterial genomes and microbiomes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/biology11111681pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/55327
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationFCT ALG-01-0145-FEDER-028824pt_PT
dc.relationFCT UI/BD/153078/2022pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleEstuarine Aquacultures at the Crossroads of Animal Production and Antibacterial Resistance: A Metagenomic Approach to the Resistomept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11pt_PT
oaire.citation.startPage1681pt_PT
oaire.citation.titleBiologypt_PT
oaire.citation.volume11pt_PT
person.familyNameDomingues
person.familyNameDionísio
person.familyNameVitorino Nogueira
person.givenNameCélia
person.givenNameFrancisco
person.givenNameTeresa Isabel
person.identifierA-2129-2009
person.identifierG-2273-2010
person.identifier.ciencia-id3416-6299-1379
person.identifier.ciencia-id7413-DB46-16E0
person.identifier.ciencia-idF211-4E18-2C69
person.identifier.orcid0000-0003-2970-010X
person.identifier.orcid0000-0002-3653-1511
person.identifier.orcid0000-0002-0059-5177
person.identifier.scopus-author-id6506790127
person.identifier.scopus-author-id7004351448
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4c8102d8-7751-4c14-9fde-9c61488e17b1
relation.isAuthorOfPublicationaa2a19c2-e8bf-4b68-98f3-737d4515e13e
relation.isAuthorOfPublicationfd1c0a47-fb41-49e1-a4c9-2575917bc120
relation.isAuthorOfPublication.latestForDiscoveryfd1c0a47-fb41-49e1-a4c9-2575917bc120

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