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EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders

2023Journal article Open access
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dc.contributor.authorKuiper, Jonas J. W.
dc.contributor.authorPrinz, Jörg C.
dc.contributor.authorStratikos, Efstratios
dc.contributor.authorKuśnierczyk, Piotr
dc.contributor.authorArakawa, Akiko
dc.contributor.authorSpringer, Sebastian
dc.contributor.authorMintoff, Dillon
dc.contributor.authorPadjen, Ivan
dc.contributor.authorShumnalieva, Russka
dc.contributor.authorVural, Seçil
dc.contributor.authorKötter, Ina
dc.contributor.authorvan de Sande, Marleen G.
dc.contributor.authorBoyvat, Ayşe
dc.contributor.authorde Boer, Joke H.
dc.contributor.authorBertsias, George
dc.contributor.authorde Vries, Niek
dc.contributor.authorKrieckaert, Charlotte L. M.
dc.contributor.authorLeal, Ines
dc.contributor.authorVidovič Valentinčič, Nataša
dc.contributor.authorTugal-Tutkun, Ilknur
dc.contributor.authorel Khaldi Ahanach, Hanane
dc.contributor.authorCostantino, Félicie
dc.contributor.authorGlatigny, Simon
dc.contributor.authorMrazovac Zimak, Danijela
dc.contributor.authorLötscher, Fabian
dc.contributor.authorKerstens, Floor G.
dc.contributor.authorBakula, Marija
dc.contributor.authorVieira De Sousa, Elsa Cristina
dc.contributor.authorBöhm, Peter
dc.contributor.authorBosman, Kees
dc.contributor.authorKenna, Tony J.
dc.contributor.authorPowis, Simon J.
dc.contributor.authorBreban, Maxime
dc.contributor.authorGul, Ahmet
dc.contributor.authorBowes, John
dc.contributor.authorLories, Rik J. U.
dc.contributor.authorNowatzky, Johannes
dc.contributor.authorWolbink, Gerrit Jan
dc.contributor.authorMcGonagle, Dennis G.
dc.contributor.authorTurkstra, Franktien
dc.date.accessioned2023-07-18T11:35:30Z
dc.date.available2023-07-18T11:35:30Z
dc.date.issued2023
dc.description© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.pt_PT
dc.description.abstractThe 'MHC-I (major histocompatibility complex class I)-opathy' concept describes a family of inflammatory conditions with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. Classical MHC-I-opathies such as spondyloarthritis, Behçet's disease, psoriasis and birdshot uveitis are widely recognised for their strong association with certain MHC-I alleles and gene variants of the antigen processing aminopeptidases ERAP1 and ERAP2 that implicates altered MHC-I peptide presentation to CD8+T cells in the pathogenesis. Progress in understanding the cause and treatment of these disorders is hampered by patient phenotypic heterogeneity and lack of systematic investigation of the MHC-I pathway.Here, we discuss new insights into the biology of MHC-I-opathies that strongly advocate for disease-overarching and integrated molecular and clinical investigation to decipher underlying disease mechanisms. Because this requires transformative multidisciplinary collaboration, we introduce the EULAR study group on MHC-I-opathies to unite clinical expertise in rheumatology, dermatology and ophthalmology, with fundamental and translational researchers from multiple disciplines such as immunology, genomics and proteomics, alongside patient partners. We prioritise standardisation of disease phenotypes and scientific nomenclature and propose interdisciplinary genetic and translational studies to exploit emerging therapeutic strategies to understand MHC-I-mediated disease mechanisms. These collaborative efforts are required to address outstanding questions in the etiopathogenesis of MHC-I-opathies towards improving patient treatment and prognostication.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAnn Rheum Dis . 2023 Jul;82(7):887-896pt_PT
dc.identifier.doi10.1136/ard-2022-222852pt_PT
dc.identifier.eissn1468-2060
dc.identifier.issn0003-4967
dc.identifier.urihttp://hdl.handle.net/10451/58651
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.relation.publisherversionhttps://ard.bmj.com/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectArthritis, Psoriaticpt_PT
dc.subjectBehcet Syndromept_PT
dc.subjectImmune System Diseasespt_PT
dc.subjectSpondylitis, Ankylosingpt_PT
dc.titleEULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borderspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage896pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage887pt_PT
oaire.citation.titleAnnals of the Rheumatic Diseasespt_PT
oaire.citation.volume82pt_PT
person.familyNameLeal
person.familyNameVieira de Sousa
person.givenNameInes
person.givenNameElsa Cristina
person.identifier.ciencia-idCD11-9FB8-5416
person.identifier.ciencia-id1519-509A-8B89
person.identifier.orcid0000-0001-9622-8779
person.identifier.orcid0000-0002-7170-8802
person.identifier.scopus-author-id57187966600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication414fec05-b51d-485e-8650-d19110a861aa
relation.isAuthorOfPublication8b9873ad-2667-48e6-aece-a73dec6a8296
relation.isAuthorOfPublication.latestForDiscovery8b9873ad-2667-48e6-aece-a73dec6a8296

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