A carregar...
Publicação
Particle coating processes
Orientador(es)
Resumo(s)
This work addresses the understanding of particle coating processes applied to nanopharmaceuticals. In a review of current research work in the field; we focus on the use of coating polymers employed in nanoparticles; nanospheres; microspheres; and microparticles; and highlight the use of liposome as biological membrane vehicles for drug delivery systems. From our investigation we concluded that Poly (ethylene glycol) (PEG) and Poly (lactic-co-glycolic acid) (PLGA) are the most frequently employed coating types. PEG coated carriers were known to have a more prolonged circulation half-time in blood and a reduced rate of uptake by the liver when compared to non-coated carriers. We also found that pharmacokinetic and pharmacodynamic profiles could be improved by the use of PLGA-based nanopar- ticles; namely as a vaccine delivery system; and to coat particles that form the basis for the treatment of diverse pathologies such as Cancer; Inflammatory and Cardiovascular Diseases (CVD). Polymeric nanoparticles were studied extensively as targeted and sustained drug delivery systems for the effec- tive drug delivery to the target with minimum side effects. We finalise the review presenting views on the future development of nanopharmaceutics and their application in the area of Cancer and Human Immunodeficiency Virus (HIV).
Descrição
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014
Palavras-chave
Liposome Mestrado Integrado - 2014 Microparticles Microspheres Nanoparticles Nanospheres Particle-Coating