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Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia

2022Artigo científico Acesso aberto
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dc.contributor.authorWhiteside, David J.
dc.contributor.authorMalpetti, Maura
dc.contributor.authorJones, P. Simon
dc.contributor.authorGhosh, Boyd C. P.
dc.contributor.authorCoyle‐Gilchrist, Ian
dc.contributor.authorvan Swieten, John C.
dc.contributor.authorSeelaar, Harro
dc.contributor.authorJiskoot, Lize
dc.contributor.authorBorroni, Barbara
dc.contributor.authorSanchez‐Valle, Raquel
dc.contributor.authorMoreno, Fermin
dc.contributor.authorLaforce, Robert
dc.contributor.authorGraff, Caroline
dc.contributor.authorSynofzik, Matthis
dc.contributor.authorGalimberti, Daniela
dc.contributor.authorMasellis, Mario
dc.contributor.authorTartaglia, Maria Carmela
dc.contributor.authorFinger, Elizabeth
dc.contributor.authorVandenberghe, Rik
dc.contributor.authorDe Mendonça, Alexandre
dc.contributor.authorTagliavini, Fabrizio
dc.contributor.authorButler, Chris R.
dc.contributor.authorSantana, Isabel
dc.contributor.authorBer, Isabelle Le
dc.contributor.authorGerhard, Alexander
dc.contributor.authorDucharme, Simon
dc.contributor.authorLevin, Johannes
dc.contributor.authorDanek, Adrian
dc.contributor.authorOtto, Markus
dc.contributor.authorSorbi, Sandro
dc.contributor.authorPasquier, Florence
dc.contributor.authorBouzigues, Arabella
dc.contributor.authorRussell, Lucy L.
dc.contributor.authorRohrer, Jonathan D.
dc.contributor.authorRowe, James B.
dc.contributor.authorRittman, Timothy
dc.date.accessioned2022-11-22T14:58:55Z
dc.date.available2022-11-22T14:58:55Z
dc.date.issued2022
dc.description© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.pt_PT
dc.description.abstractIntroduction: We tested whether changes in functional networks predict cognitive decline and conversion from the presymptomatic prodrome to symptomatic disease in familial frontotemporal dementia (FTD). Methods: For hypothesis generation, 36 participants with behavioral variant FTD (bvFTD) and 34 controls were recruited from one site. For hypothesis testing, we studied 198 symptomatic FTD mutation carriers, 341 presymptomatic mutation carriers, and 329 family members without mutations. We compared functional network dynamics between groups, with clinical severity and with longitudinal clinical progression. Results: We identified a characteristic pattern of dynamic network changes in FTD, which correlated with neuropsychological impairment. Among presymptomatic mutation carriers, this pattern of network dynamics was found to a greater extent in those who subsequently converted to the symptomatic phase. Baseline network dynamic changes predicted future cognitive decline in symptomatic participants and older presymptomatic participants. Discussion: Dynamic network abnormalities in FTD predict cognitive decline and symptomatic conversion. Highlights: We investigated brain network predictors of dementia symptom onset Frontotemporal dementia results in characteristic dynamic network patterns Alterations in network dynamics are associated with neuropsychological impairment Network dynamic changes predict symptomatic conversion in presymptomatic carriers Network dynamic changes are associated with longitudinal cognitive decline.pt_PT
dc.description.sponsorshipGENFI was funded by the Medical Research Council UK (MR/M023664/1), the Bluefield Project, the JPND GENFI-PROX grant (by DLR/BMBF 2019-02248) and by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy – ID 390857198). The study was co-funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge (BRC-1215-20014), the Cambridge Centre for Parkinson-plus (RG95450); the Wellcome Trust (220258); the Evelyn Trust (17/09) and Medical Research Council (SUAG/092 116768).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlzheimer's Dement. 2022; 1- 16pt_PT
dc.identifier.doi10.1002/alz.12824pt_PT
dc.identifier.eissn1552-5279
dc.identifier.issn1552-5260
dc.identifier.urihttp://hdl.handle.net/10451/55205
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://alz-journals.onlinelibrary.wiley.com/journal/15525279pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDisease progressionpt_PT
dc.subjectFrontotemporal dementiapt_PT
dc.subjectFunctional magnetic resonance imaging (fMRI)pt_PT
dc.subjectNetwork dynamicspt_PT
dc.subjectPresymptomaticpt_PT
dc.titleTemporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementiapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleAlzheimer's & Dementiapt_PT
person.familyNamede Mendonça
person.givenNameAlexandre
person.identifier.ciencia-id1615-41B4-0848
person.identifier.orcid0000-0002-0488-1453
person.identifier.scopus-author-id7003320823
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication53ca3547-99ce-4b68-9330-7879a54c47b7
relation.isAuthorOfPublication.latestForDiscovery53ca3547-99ce-4b68-9330-7879a54c47b7

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