Logo do repositório
 
Publicação

Group 1 innate lymphoid cell lineage identity is determined by a cis-regulatory element marked by a long non-coding RNA

2017Artigo científico Acesso restrito
Ver registo simples
dc.contributor.authorMowel, Walter K.
dc.contributor.authorMcCright, Sam J.
dc.contributor.authorKotzin, Jonathan J.
dc.contributor.authorCollet, Magalie A.
dc.contributor.authorUyar, Asli
dc.contributor.authorChen, Xin
dc.contributor.authorDeLaney, Alexandra
dc.contributor.authorSpencer, Sean P.
dc.contributor.authorVirtue, Anthony T.
dc.contributor.authorYang, EnJun
dc.contributor.authorVillarino, Alejandro
dc.contributor.authorKurachi, Makoto
dc.contributor.authorDunagin, Margaret C.
dc.contributor.authorPritchard, Gretchen Harms
dc.contributor.authorStein, Judith
dc.contributor.authorHughes, Cynthia
dc.contributor.authorFonseca-Pereira, Diogo
dc.contributor.authorVeiga-Fernandes, Henrique
dc.contributor.authorRaj, Arjun
dc.contributor.authorKambayashi, Taku
dc.contributor.authorBrodsky, Igor E.
dc.contributor.authorO’Shea, John J.
dc.contributor.authorWherry, E. John
dc.contributor.authorGoff, Loyal A.
dc.contributor.authorRinn, John L.
dc.contributor.authorWilliams, Adam
dc.contributor.authorFlavell, Richard A.
dc.contributor.authorHenao-Mejia, Jorge
dc.date.accessioned2022-09-07T15:23:44Z
dc.date.available2022-09-07T15:23:44Z
dc.date.issued2017
dc.description© 2017 Elsevier Inc.pt_PT
dc.description.abstractCommitment to the innate lymphoid cell (ILC) lineage is determined by Id2, a transcriptional regulator that antagonizes T and B cell-specific gene expression programs. Yet how Id2 expression is regulated in each ILC subset remains poorly understood. We identified a cis-regulatory element demarcated by a long non-coding RNA (lncRNA) that controls the function and lineage identity of group 1 ILCs, while being dispensable for early ILC development and homeostasis of ILC2s and ILC3s. The locus encoding this lncRNA, which we termed Rroid, directly interacted with the promoter of its neighboring gene, Id2, in group 1 ILCs. Moreover, the Rroid locus, but not the lncRNA itself, controlled the identity and function of ILC1s by promoting chromatin accessibility and deposition of STAT5 at the promoter of Id2 in response to interleukin (IL)-15. Thus, non-coding elements responsive to extracellular cues unique to each ILC subset represent a key regulatory layer for controlling the identity and function of ILCs.pt_PT
dc.description.sponsorshipThe work in this manuscript was supported by funds from CHOP, UPenn IFI and IDOM pilot projects, the PEW Foundation, and NIH R21AI128060, R21DK111755, and R01HL136572 (J.H.-M.). A.W. and R.A.F. were supported by NIH R21AI110776; R.A.F. by the Howard Hughes Medical Institute; I.E.B. by NIH R01AI103062 and R01AI128530; W.K.M. by NIH T32AI055428 and F31AI124538; J.J.K. by NIH T32DK007780; S.P.S. by NIH F30DK094708; and A.R. and M.C.D. by New Innovator NIH DP2OD008514, NIH R33EB019767, and NSF CAREER 1350601. E.J.W. is a member of the Parker Institute for Cancer Immunotherapy, which supports the Penn Cancer Immunotherapy Program. H.V.-F. is funded by ERC (647274), EU; Kenneth Rainin Foundation, US; Crohn’s and Colitis Foundation of America, US; and FCT, Portugal. A.R. receives royalty and consulting income related to Stellaris RNA FISH probes from LGC/Biosearch Technologies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationImmunity. 2017 Sep 19;47(3):435-449.e8pt_PT
dc.identifier.doi10.1016/j.immuni.2017.08.012pt_PT
dc.identifier.eissn1097-4180
dc.identifier.issn1074-7613
dc.identifier.urihttp://hdl.handle.net/10451/54367
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationGlia-derived factors in innate lymphoid cell sensing and intestinal defence
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/immunitypt_PT
dc.subjectILC1pt_PT
dc.subjectId2pt_PT
dc.subjectInnate lymphoid cellspt_PT
dc.subjectLineage identitypt_PT
dc.subjectlncRNApt_PT
dc.subjectTranscriptional regulationpt_PT
dc.titleGroup 1 innate lymphoid cell lineage identity is determined by a cis-regulatory element marked by a long non-coding RNApt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleGlia-derived factors in innate lymphoid cell sensing and intestinal defence
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/647274/EU
oaire.citation.endPage449.e8pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage435pt_PT
oaire.citation.titleImmunitypt_PT
oaire.citation.volume47pt_PT
oaire.fundingStreamH2020
person.familyNamePereira
person.familyNameVeiga-Fernandes
person.givenNameDiogo
person.givenNameHenrique
person.identifier.ciencia-idC919-1B92-794F
person.identifier.orcid0000-0002-7400-9804
person.identifier.orcid0000-0001-6216-1836
person.identifier.ridU-1275-2018
person.identifier.scopus-author-id55538773600
person.identifier.scopus-author-id6508113770
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0bc7806d-bc67-4521-b3b8-67432bc6973b
relation.isAuthorOfPublicatione33cff40-943e-4de1-b0e3-af20b294c0cf
relation.isAuthorOfPublication.latestForDiscovery0bc7806d-bc67-4521-b3b8-67432bc6973b
relation.isProjectOfPublicationc24f9361-0173-4bae-a0e2-0c575ad55baa
relation.isProjectOfPublication.latestForDiscoveryc24f9361-0173-4bae-a0e2-0c575ad55baa

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
Group_1.pdf
Tamanho:
5.65 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.2 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

IMM - Artigos em Revistas Internacionais
FM - Artigos em Revistas Internacionais